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Titolo:
KEITH-R-PORTER-LECTURE, 1996 - OF MICE AND MEN - GENETIC-DISORDERS OFTHE CYTOSKELETON
Autore:
FUCHS E;
Indirizzi:
UNIV CHICAGO,HOWARD HUGHES MED INST,DEPT MOL GENET & CELL BIOL CHICAGO IL 60637
Titolo Testata:
Molecular biology of the cell
fascicolo: 2, volume: 8, anno: 1997,
pagine: 189 - 203
SICI:
1059-1524(1997)8:2<189:K1-OMA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMOLYSIS-BULLOSA SIMPLEX; KERATIN INTERMEDIATE FILAMENTS; STRATIFIED SQUAMOUS EPITHELIA; HUMAN-HAIR FOLLICLE; WHITE SPONGE NEVUS; EPIDERMAL KERATIN; TRANSGENIC MICE; ICHTHYOSIS BULLOSA; CULTURED-CELLS; COILED-COIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
113
Recensione:
Indirizzi per estratti:
Citazione:
E. Fuchs, "KEITH-R-PORTER-LECTURE, 1996 - OF MICE AND MEN - GENETIC-DISORDERS OFTHE CYTOSKELETON", Molecular biology of the cell, 8(2), 1997, pp. 189-203

Abstract

Since the time when I was a postdoctoral fellow under the supervisionof Dr. Howard Green, then at the Massachusetts Institute of Technology, I have been interested in understanding the molecular mechanisms underlying growth, differentiation, and development in the mammalian ectoderm. The ectoderm gives rise to epidermal keratinocytes and to neurons, which are the only two cell types of the body that devote most of their protein-synthesizing machinery to developing an elaborate cytoskeletal architecture composed of 10-nm intermediate filaments (Ifs). Our interest is in understanding the architecture of the cytoskeleton inkeratinocytes and in neurons, and in elucidating how perturbations inthis architecture can lead to degenerative diseases of the skin and the nervous system. I will concentrate on the intermediate filament network of the skin and its associated genetic disorders, since this has been a long-standing interest of my laboratory at the University of Chicago.

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Documento generato il 30/10/20 alle ore 00:37:49