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Titolo:
INCREASED ACTIVATION OF L-TYPE VOLTAGE-DEPENDENT CALCIUM CHANNELS IS ASSOCIATED WITH GLYCINE ENHANCEMENT OF N-METHYL-D-ASPARTATE-STIMULATEDDOPAMINE RELEASE IN GLOBAL CEREBRAL ISCHEMIA REPERFUSION/
Autore:
WERLING LL; HOEHNER PJ; HURT KJ; FOX LG; BLANCK TJJ; ROSENTHAL RE; FISKUM G;
Indirizzi:
GEORGE WASHINGTON UNIV,MED CTR,DEPT PHARMACOL,2300 EYE ST NW WASHINGTON DC 20037 GEORGE WASHINGTON UNIV,MED CTR,DEPT BIOCHEM & MOLEC BIOL WASHINGTON DC 20037 GEORGE WASHINGTON UNIV,MED CTR,DEPT EMERGENCY MED WASHINGTON DC 20037 JOHNS HOPKINS UNIV,INST MED,DEPT ANESTHESIOL & CRIT CARE MED BALTIMORE MD 00000
Titolo Testata:
Journal of neurochemistry
fascicolo: 1, volume: 63, anno: 1994,
pagine: 215 - 221
SICI:
0022-3042(1994)63:1<215:IAOLVC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIENT FOREBRAIN ISCHEMIA; RAT STRIATAL SLICES; NMDA RECEPTOR; XENOPUS-OOCYTES; NEURONAL DAMAGE; REPERFUSION; BRAIN; NIMODIPINE; GLUTAMATE; BINDING;
Keywords:
GLOBAL CEREBRAL ISCHEMIA; DOPAMINE RELEASE; VOLTAGE-DEPENDENT CALCIUM CHANNELS; NITRENDIPINE; PN200-110; NMDA RECEPTOR/CHANNEL COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
L.L. Werling et al., "INCREASED ACTIVATION OF L-TYPE VOLTAGE-DEPENDENT CALCIUM CHANNELS IS ASSOCIATED WITH GLYCINE ENHANCEMENT OF N-METHYL-D-ASPARTATE-STIMULATEDDOPAMINE RELEASE IN GLOBAL CEREBRAL ISCHEMIA REPERFUSION/", Journal of neurochemistry, 63(1), 1994, pp. 215-221

Abstract

We investigated the relationships among N-methyl-D-aspartate, glycine, L-type voltage-dependent calcium channels, and [H-3]dopamine releasein a canine model of global cerebral ischemia/reperfusion. The binding of [H-3]PN200-110 ([H-3]isradipine) to L-type voltage-dependent calcium channels, that open as a consequence of N-methyl-D-aspartate-induced changes in membrane potential, was approximately doubled in striatal membranes prepared from ischemic animals relative to controls, and remained significantly elevated at 30 min and 2 h of reperfusion. Thesechanges coincided temporally with changes in the ability of the voltage-sensitive calcium channel blocker nitrendipine to inhibit glycine enhancement of N-methyl-D-aspartate-stimulated [H-3]dopamine release instriatal slices prepared from the same animals. Compared with nonischemic controls, N-methyl-D-aspartate-stimulated [H-3]dopamine release was increased in ischemic animals and remained increased throughout reperfusion up to at least 24 h. Glycine enhanced N-methyl-D-aspartate-stimulated release in all treatment groups. The enhancement of N-methyl-D-aspartate-stimulated dopamine release by glycine was reduced by the inclusion of nitrendipine in striatal slices from ischemic and 30-min reperfused animals. These data suggest that glycine may facilitate opening of the voltage-dependent calcium channels activated by N-methyl-D-aspartate and that this facilitation is blocked by the antagonist nitrendipine.

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Documento generato il 28/11/20 alle ore 22:02:04