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Titolo:
PRIMARY CENTRAL-NERVOUS-SYSTEM MALIGNANT NON-HODGKINS-LYMPHOMAS FROM HIV-INFECTED AND NONINFECTED PATIENTS - EXPRESSION OF CELLULAR-SURFACEPROTEINS AND EPSTEIN-BARR VIRAL MARKERS
Autore:
AUPERIN I; MIKOL J; OKSENHENDLER E; THIEBAUT JB; BRUNET M; DUPONT B; MORINET F;
Indirizzi:
UNIV PARIS 07,HOP LARIBOISIERE,DEPT PATHOL,SERV CENT ANAT PATHOL,2 RUE AMBROISE PARE F-75475 PARIS 10 FRANCE UNIV PARIS 07,HOP LARIBOISIERE,DEPT PATHOL,SERV CENT ANAT PATHOL F-75475 PARIS 10 FRANCE UNIV PARIS 07,HOP ST LOUIS,DEPT BACTERIOL & VIROL PARIS FRANCE UNIV PARIS 07,HOP ST LOUIS,DEPT CLIN IMMUNOL PARIS FRANCE HENRY DUNANT HOSP,DEPT NEUROSURG PARIS FRANCE PASTEUR HOSP,DEPT INTERNAL MED PARIS FRANCE
Titolo Testata:
Neuropathology and applied neurobiology
fascicolo: 3, volume: 20, anno: 1994,
pagine: 243 - 252
SICI:
0305-1846(1994)20:3<243:PCMNFH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; PRIMARY CEREBRAL LYMPHOMA; PRIMARY BRAIN LYMPHOMA; ORGAN-TRANSPLANTATION; INSITU HYBRIDIZATION; VIRUS-DNA; AIDS; LATENT; CELLS;
Keywords:
PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMAS; HIV INFECTION; EBV; ADHESION MOLECULES; ACTIVATION MOLECULES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
I. Auperin et al., "PRIMARY CENTRAL-NERVOUS-SYSTEM MALIGNANT NON-HODGKINS-LYMPHOMAS FROM HIV-INFECTED AND NONINFECTED PATIENTS - EXPRESSION OF CELLULAR-SURFACEPROTEINS AND EPSTEIN-BARR VIRAL MARKERS", Neuropathology and applied neurobiology, 20(3), 1994, pp. 243-252

Abstract

The increased incidence of primary central nervous system malignant non-Hodgkin's lymphomas (PCNSL) in HIV- and non-HIV-infected patients and the demonstration of Epstein-Barr virus (EBV) in these tumours may indicate relationships between PCNSL and EBV. Consequently expression of EBV-induced antigens and cellular markers were studied in 11 HN-infected and seven non-infected patients by in situ hybridization (ISH) and immunocytochemistry in monoclonal B cell PCNSL. In HIV-infected patients EBV genome was present in 9/11 cases, LMP in 11/11 cases and EBNA2 in 10/11 cases. The expression of adhesion and activation moleculeswas low or absent. In HIV non-infected patients, EBV genome was present in 5/7 cases, with IMP in 4/7 cases. EBNA2 was never detected. All these lymphomas expressed LFAlbeta. Whatever the population, no lytic cycle EBV markers were detected. Compared with other types of EBV lymphomas, our results suggest a different EBV latency state in primary E cell lymphomas of the CNS from HIV-infected or non-infected patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 11:00:47