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Titolo:
SUSCEPTIBILITY OF HUMAN COLON-CARCINOMA CELLS TO ANTICANCER DRUGS IS ENHANCED BY L-HISTIDINOL
Autore:
WARRINGTON RC; CHENG I; FANG WD;
Indirizzi:
UNIV SASKATCHEWAN,DEPT BIOCHEM SASKATOON S7N 0W0 SK CANADA UNIV SASKATCHEWAN,CANC RES UNIT SASKATOON S7N 0W0 SK CANADA
Titolo Testata:
Anticancer research
fascicolo: 2A, volume: 14, anno: 1994,
pagine: 367 - 372
SICI:
0250-7005(1994)14:2A<367:SOHCCT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL CANCER-CHEMOTHERAPY; MULTIDRUG-RESISTANT PHENOTYPE; MURINE BREAST-TUMORS; INFUSED L-HISTIDINOL; PROLIFERATION DEPENDENCE; MICE; 5-FLUOROURACIL; EFFICACY; B16F10-MELANOMA; SELECTIVITY;
Keywords:
COLON CARCINOMA; L-HISTIDINOL; 5-FLUOROURACIL; ANTICANCER DRUGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
R.C. Warrington et al., "SUSCEPTIBILITY OF HUMAN COLON-CARCINOMA CELLS TO ANTICANCER DRUGS IS ENHANCED BY L-HISTIDINOL", Anticancer research, 14(2A), 1994, pp. 367-372

Abstract

The effects of L-histidinol on cell cycle transit and anticancer drugsusceptibility of four cultured human colon carcinoma cell lines havebeen examined. The lines studied included two lines, SW480 and SW620,which were derived from the same patient as a grade 111 adenocarcinoma of the colon and a lymphatic metastatic form of colon carcinoma, respectively, as well as the human colon adenocarcinoma lines HT-29 and WiDr. L-Histidinol accentuates the vulnerability of all of these human carcinoma lines to several different classes of anticancer drugs, including 5-fluorouracil, the most effective and most commonly used singleagent for metastatic colon carcinoma. The ability of L-histidinol to accentuate the sensitivity of these colocarcinoma lines to anticancer drugs, including those which are cell cycle-dependent, is in apparent contradiction to the finding that L-histidinol markedly slows cycle transit in all lines tested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:02:35