Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECTS OF ZOTEPINE, HALOPERIDOL AND CLOZAPINE ON MK-801-INDUCED STEREOTYPY AND LOCOMOTION IN RATS
Autore:
GATTAZ WF; SCHUMMER B; BEHRENS S;
Indirizzi:
CENT INST MENTAL HLTH,NEUROBIOL UNIT,POB 122120 D-68072 MANNHEIM GERMANY
Titolo Testata:
Journal of neural transmission
fascicolo: 3, volume: 96, anno: 1994,
pagine: 227 - 232
SICI:
0300-9564(1994)96:3<227:EOZHAC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MK-801; RECEPTOR; PHENCYCLIDINE; ANTAGONIST;
Keywords:
MK-801; NMDA-RECEPTOR; STEREOTYPIES; ZOTEPINE; HALOPERIDOL; CLOZAPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
W.F. Gattaz et al., "EFFECTS OF ZOTEPINE, HALOPERIDOL AND CLOZAPINE ON MK-801-INDUCED STEREOTYPY AND LOCOMOTION IN RATS", Journal of neural transmission, 96(3), 1994, pp. 227-232

Abstract

In the present study we compared the effects of the atypical neuroleptic zotepine to haloperidol and clozapine on stereotypies and locomotion induced in rats by the N-methyl-D-aspartate (NMDA) antagonist MK-801. Zotepine caused a dose-dependent reduction of MK-801-induced stereotypies and locomotion. Zotepine at a dosis of 2.5 mg/kg body weight showed a similar effect to 0.25 mg/kg haloperidol in reducing sterotypies and locomotion. Clozapine (5.0 mg/kg) reduced significantly locomotion and non-significantly stereotypies. These results add support to the assumption that MK-801-induced behavior provides an adequate animal model to test the potential efficacy of typical and atypical neuroleptics in the treatment of psychoses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:29:08