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Titolo:
THE 5-HT1A RECEPTOR ANTAGONIST (S)-UH-301 BLOCKS THE (R)-8-OH-DPAT-INDUCED INHIBITION OF SEROTONERGIC DORSAL RAPHE CELL FIRING IN THE RAT
Autore:
ARBORELIUS L; HOOK BB; HACKSELL U; SVENSSON TH;
Indirizzi:
KAROLINSKA INST,DEPT PHYSIOL & PHARMACOL,DIV PHARMACOL S-17177 STOCKHOLM SWEDEN KAROLINSKA INST,DEPT PHYSIOL & PHARMACOL,DIV PHARMACOL S-17177 STOCKHOLM SWEDEN UPPSALA UNIV,DEPT ORGAN PHARMACEUT CHEM UPPSALA SWEDEN
Titolo Testata:
Journal of neural transmission
fascicolo: 3, volume: 96, anno: 1994,
pagine: 179 - 186
SICI:
0300-9564(1994)96:3<179:T5RA(B>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTSYNAPTIC 5-HT(1A) RECEPTORS; NEURONS; BRAIN; AUTORECEPTORS; NUCLEUS; (S)-5-FLUORO-8-HYDROXY-2-(DIPROPYLAMINO)TETRALIN; RESPONSES; AGONISTS; SYSTEM; INVIVO;
Keywords:
5-HT1A; 8-OH-DPAT; (S)-UH-301; 5-HT1A RECEPTOR ANTAGONIST; ELECTROPHYSIOLOGY; DORSAL RAPHE NUCLEUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
L. Arborelius et al., "THE 5-HT1A RECEPTOR ANTAGONIST (S)-UH-301 BLOCKS THE (R)-8-OH-DPAT-INDUCED INHIBITION OF SEROTONERGIC DORSAL RAPHE CELL FIRING IN THE RAT", Journal of neural transmission, 96(3), 1994, pp. 179-186

Abstract

(S)-UH-301 [(S)-5-fluoro-8-hydroxy-2-(dipropylamino) 0.5-4.0 mg/kg i.v.] did not significantly alter the firing rate of 5-hydroxytryptamine(5-HT) containing neurons in the dorsal raphe nucleus (DRN) as a group, although some individual cells were activated whereas others were depressed. However, (S)-UH-301 (2.0 mg/kg i.v.) consistently reversed the inhibition of DRN-5-HT cells produced by the selective 5-HT1A receptor agonist (R)-8-OH-DPAT (0.5 mu g/kg i.v.) and the dose-response curve for this effect of (R)-8-OH-DPAT was markedly shifted to the right by pretreatment with (S)-UH-301 (1.0 mg/kg i.v.). These results support the notion that (S)-UH-301 acts as an antagonist at central 5-HT1A receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:15:50