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Titolo:
COMPLEMENT AND ANTIBODY IN NEUTROPHIL-MEDIATED KILLING OF TYPE-V GROUP-B STREPTOCOCCUS
Autore:
HALL MA; HICKMAN ME; BAKER CJ; EDWARDS MS;
Indirizzi:
BAYLOR COLL MED,DEPT PEDIAT,INFECT DIS SECT,1 BAYLOR PLAZA,ROOM 307E HOUSTON TX 77030 BAYLOR COLL MED,DEPT PEDIAT,INFECT DIS SECT HOUSTON TX 77030
Titolo Testata:
The Journal of infectious diseases
fascicolo: 1, volume: 170, anno: 1994,
pagine: 88 - 93
SICI:
0022-1899(1994)170:1<88:CAAINK>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROVISIONAL TYPE-V; OPSONOPHAGOCYTOSIS; SEROTYPES; RECEPTOR; IV; PARTICIPATION; STRAINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Hall et al., "COMPLEMENT AND ANTIBODY IN NEUTROPHIL-MEDIATED KILLING OF TYPE-V GROUP-B STREPTOCOCCUS", The Journal of infectious diseases, 170(1), 1994, pp. 88-93

Abstract

Serious infections caused by type V group B streptococci (GBS) are increasing. The requirements for antibody, complement, and neutrophil receptors in the killing of 12 clinical type V GBS isolates were investigated. When tested at concentrations of 33%, 5% and 1%, a human serum pool promoted neutrophil-mediated killing of the 12 isolates at a meanof 83% +/- 9%, 77% +/- 17%, and 14% +/- 28%, respectively. Addition of heated immune rabbit serum to the 5% or 1% pool increased killing significantly (97% +/- 2% or 80% +/- 15%, respectively, P < .01). With hypogammaglobulinemic serum, complement-mediated killing ranged from 74% +/- 2% for a strain designated resistant to 98% +/- 1% for a strain designated sensitive. Neutrophil-mediated killing was not altered by use of human sera deficient in C4 or C7 but was reduced significantly with C3-deficient serum (P < .05). Maximal inhibition of neutrophil-mediated killing was observed by monoclonal antibody blockade of complement receptor (CR) 3 alone or in combination with CR1 or Fc receptor III. Thus, C3 is required and specific antibody promotes neutrophil-mediated killing of type V GBS. Neutrophil CR3 and either CR1 or Fc receptor III optimize phagocytosis. A number of host responses function in concert to effect optimal neutrophil-mediated killing of clinical isolates of type V GBS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 00:15:55