Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CORTICOSTERONE INCREASES SEVERITY OF ACUTE WITHDRAWAL FROM ETHANOL, PENTOBARBITAL, AND DIAZEPAM IN MICE
Autore:
ROBERTS AJ; CRABBE JC; KEITH LD;
Indirizzi:
OREGON HLTH SCI UNIV,DEPT MED PSYCHOL PORTLAND OR 97201 OREGON HLTH SCI UNIV,DEPT PHARMACOL PORTLAND OR 97201 OREGON HLTH SCI UNIV,DEPT MED PORTLAND OR 97201 DEPT VET AFFAIRS MED CTR PORTLAND OR 97201
Titolo Testata:
Psychopharmacology
fascicolo: 1-2, volume: 115, anno: 1994,
pagine: 278 - 284
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; INDUCED CONVULSIONS; ALCOHOL-WITHDRAWAL; INDUCED SEIZURES; GABA RECEPTOR; UNIT-ACTIVITY; WSR MICE; GLUCOCORTICOIDS; CORTISOL; DEPENDENCE;
Keywords:
SUBSTANCE WITHDRAWAL SYNDROME; CORTICOSTERONE; ETHANOL; PENTOBARBITAL; DIAZEPAM; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Roberts et al., "CORTICOSTERONE INCREASES SEVERITY OF ACUTE WITHDRAWAL FROM ETHANOL, PENTOBARBITAL, AND DIAZEPAM IN MICE", Psychopharmacology, 115(1-2), 1994, pp. 278-284

Abstract

It has been suggested that withdrawal from several subclasses of central nervous system (CNS) depressants involves common underlying mechanisms. For example, mice genetically selected for severe ethanol withdrawal convulsions (Withdrawal Seizure Prone or WSP) have also been found to express severe withdrawal following treatment with barbiturates and benzodiazepines. Corticosteroids appear to modulate severity of withdrawal from CNS depressants. Therefore, it was hypothesized that corticosterone would enhance withdrawal convulsions following acute ethanol, pentobarbital, and diazepam in WSP mice. Corticosterone (20 mg/kg) administered following each of these drugs significantly increased severity of handling-induced convulsions during withdrawal. Corticosterone did not affect pre-withdrawal convulsion scores or handling-induced convulsions of drug-naive mice. These results suggest that withdrawal convulsions following acute ethanol, pentobarbital, and diazepam are sensitive to modulation by corticosterone and they support the hypothesis that stress may increase drug withdrawal severity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:34:44