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Titolo:
LOW-DOSES OF THE 5-HT1A AGONIST 8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN (8-OH DPAT) INCREASE ETHANOL INTAKE
Autore:
TOMKINS DM; HIGGINS GA; SELLERS EM;
Indirizzi:
ADDICT RES FDN,33 RUSSELL ST TORONTO M5S 2S1 ON CANADA UNIV TORONTO,DEPT PHARMACOL TORONTO ON CANADA UNIV TORONTO,DEPT MED TORONTO ON CANADA UNIV TORONTO,DEPT PSYCHIAT TORONTO ON CANADA
Titolo Testata:
Psychopharmacology
fascicolo: 1-2, volume: 115, anno: 1994,
pagine: 173 - 179
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL-PREFERRING P; FREE-FEEDING RATS; SEROTONIN-1A RECEPTORS; DOPAMINE ANTAGONISTS; TETRALIN 8-OH-DPAT; BRAIN-STIMULATION; BEHAVIOR; DRINKING; CONSUMPTION; PREFERENCE;
Keywords:
LIMITED ACCESS SCHEDULE; ETHANOL INTAKE; 8-OH DPAT; BEHAVIOR; 5-HT; WATER DEPRIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Tomkins et al., "LOW-DOSES OF THE 5-HT1A AGONIST 8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN (8-OH DPAT) INCREASE ETHANOL INTAKE", Psychopharmacology, 115(1-2), 1994, pp. 173-179

Abstract

Previous work has reported that the 5-hydroxytryptamine (5-HT)(1A) agonist, 8-hydroxy 2-(di-n-propylamino)tetralin (8-OH DPAT), reduces ethanol intake by rats. However, as 8-OH DPAT reduces 5-HT neurotransmission, these findings are inconsistent with the proposed inhibitory roleof central 5-HT neurons on ethanol intake. We examined the effect of 8-OH DPAT on ethanol, water and food intake in rats maintained on a limited access schedule using a lower dose range (6-250 mu g/kg) and by assessing concomitant changes in behaviour. Low doses of 8-OH DPAT enhanced ethanol intake even when food and water were offered as alternatives. Suppression in ethanol intake was observed at higher doses whereelements of the 5-HT syndrome were apparent. Similar observations were made in both fluid and non-fluid deprived water drinking rats, suggesting the tatter effect is non-selective. Therefore 8-OH DPAT may bothincrease or decrease ethanol consumption in the rat depending on the dose used.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 11:02:34