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Titolo:
A PROSPECTIVE RANDOMIZED TRIAL OF THYMOPENTIN VERSUS GRANULOCYTE - COLONY-STIMULATING FACTOR WITH OR WITHOUT THYMOPENTIN IN THE PREVENTION OF FEBRILE EPISODES IN CANCER-PATIENTS UNDERGOING HIGHLY CYTOTOXIC CHEMOTHERAPY
Autore:
GEBBIA V; TESTA A; BORSELLINO N; GEBBIA N; VALENZA R; CANNATA G;
Indirizzi:
UNIV PALERMO,POLICLIN,INST PHARMACOL,CHAIR CHEMOTHERAPY,VIA VESPRO 129 I-90127 PALERMO ITALY UNIV PALERMO,POLICLIN,SERV CHEMOTHERAPY I-90127 PALERMO ITALY
Titolo Testata:
Anticancer research
fascicolo: 2B, volume: 14, anno: 1994,
pagine: 731 - 734
SICI:
0250-7005(1994)14:2B<731:APRTOT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOTHERAPY; COMBINATION; CISPLATIN; CELL;
Keywords:
CANCER; CHEMOTHERAPY; INFECTIONS; G-CSF; THYMOPENTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
V. Gebbia et al., "A PROSPECTIVE RANDOMIZED TRIAL OF THYMOPENTIN VERSUS GRANULOCYTE - COLONY-STIMULATING FACTOR WITH OR WITHOUT THYMOPENTIN IN THE PREVENTION OF FEBRILE EPISODES IN CANCER-PATIENTS UNDERGOING HIGHLY CYTOTOXIC CHEMOTHERAPY", Anticancer research, 14(2B), 1994, pp. 731-734

Abstract

One hundred patients with advanced carcinoma undergoing highly cotoxicity chemotherapy were enrolled in a prospective randomized trial comparing subcutaneous G-CSF, thymopentin, a combination of the two, and placebo as preventive treatment of febrile leukopenia. Data from this study skew that G-CSF was very active in reducing the incidence of chemotherapy-related fever and leukopenia as compared to placebo (22% versus 64%). This difference was statistically highly significant (P < 0.001). Thymopentin was associated with a reduction in febrile episodes as compared to placebo (52% versus 64%), but this difference did nor reach statistical significance. Moreover the addition of thymopentin to G-CSF did not result in a statistically significant improvement of results obtained with G-CSF alone. Similar results were achieved for family infections. Tolerance to thymopentin was excellent, while less than9% of patients on G-CSF treatment complained of mild nausea and generalized bone pain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:18:45