Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTIMYOSIN ANTIBODY IMAGING IN EXPERIMENTAL AORTIC REGURGITATION
Autore:
LU P; ZANZONICO P; GOLDFINE SM; HARDOFF R; MAGID N; GENTILE R; HERROLD EM; BORER JS;
Indirizzi:
CORNELL UNIV,MED CTR,NEW YORK HOSP,DIV CARDIOL,COLL MED,525 E 68TH STNEW YORK NY 10021 CORNELL UNIV,MED CTR,NEW YORK HOSP,DIV CARDIOL,COLL MED NEW YORK NY 10021 CORNELL UNIV,MED CTR,NEW YORK HOSP,DIV NUCL MED,COLL MED NEW YORK NY 10021
Titolo Testata:
Journal of nuclear cardiology
fascicolo: 1, volume: 4, anno: 1997,
parte:, 1
pagine: 25 - 32
SICI:
1071-3581(1997)4:1<25:AAIIEA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-111 MONOCLONAL ANTIMYOSIN; ACUTE MYOCARDIAL-INFARCTION; MYOSIN-SPECIFIC ANTIBODY; VALVE DISEASE; DILATED CARDIOMYOPATHY; DIASTOLIC FUNCTION; HYPERTROPHIC CARDIOMYOPATHY; INTERSTITIAL FIBROSIS; PRESSURE OVERLOAD; CARDIAC MYOSIN;
Keywords:
VOLUME OVERLOAD; AORTIC REGURGITATION; CARDIAC IMAGING; ANTIMYOSIN ANTIBODY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
P. Lu et al., "ANTIMYOSIN ANTIBODY IMAGING IN EXPERIMENTAL AORTIC REGURGITATION", Journal of nuclear cardiology, 4(1), 1997, pp. 25-32

Abstract

Background. Fiber dropout and myocyte necrosis precede heart failure in experimental aortic regurgitation (AR), The current study aimed to determine whether this process can be detected by noninvasive scintigraphic imaging. Methods and Results. In-111-labeled antimyosin antibodyFab fragment (1 to 1.5 mCi) (Myoscint) was administered to each of 34New Zealand White rabbits: 11 early (3 to 5 weeks) after surgical AR induction; 9 late (98 to 128 weeks) after AR induction; 5 normal and 3sham-operated age-matched with early AR; and 3 normal and 3 sham-operated age-matched with late AR, Echocardiographic fractional shorteningwas indistinguishable among control, early AR, and late AR groups, Invivo gamma camera imaging 24 and 48 hours after isotope administration, post-mortem heart activity determination (percentage injected dose per gram), and autoradiography were performed, At 24 and 48 hours, heart-to-lung counts-per-pixel ratios from in vivo images were greater (p< 0.05) in the late AR rabbits than in each of the three other groups, No significant differences were found when early AR and older or younger control rabbits were compared, Heart activity (percentage injected dose per gram) in late AR rabbits trended toward higher values than in age-matched control rabbits (p = 0.057), but in early AR it was indistinguishable from that in the corresponding control (p = 0.413, difference not significant), The autoradiographic endocardial/epicardial activity ratio in late AR rabbits was greater than in control and earlyAR rabbits (1.27 +/- 0.13 vs 1.06 +/- 0.09 and vs 1.13 +/- 0.10, respectively, p < 0.02). Conclusions. Whereas isotope uptake in late AR rabbits differed from that in control and early AR rabbits, systolic function was indistinguishable. Thus In-111-labeled antimyosin antibody imaging may permit noninvasive detection of AR-induced myocardial damage before functional deterioration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:26:58