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Titolo:
DIAGNOSTIC-ACCURACY OF DIPYRIDAMOLE TECHNETIUM 99M-LABELED SESTAMIBI MYOCARDIAL TOMOGRAPHY FOR DETECTION OF CORONARY-ARTERY DISEASE
Autore:
MILLER DD; YOUNIS LT; CHAITMAN BR; STRATMANN H;
Indirizzi:
ST LOUIS UNIV,HLTH SCI CTR,DEPT INTERNAL MED,SCH MED,1402 S GRAND BLVD ST LOUIS MO 63104 JOHN COCHRAN VET ADM MED CTR ST LOUIS MO 00000
Titolo Testata:
Journal of nuclear cardiology
fascicolo: 1, volume: 4, anno: 1997,
parte:, 1
pagine: 18 - 24
SICI:
1071-3581(1997)4:1<18:DODT9S>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; TECHNETIUM-99M-SESTAMIBI SPECT; TL-201 TOMOGRAPHY; CHEST PAIN; EXERCISE; PERFUSION; STRESS; ISONITRILE; SAFETY; ARTERIOGRAPHY;
Keywords:
SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY; MYOCARDIAL PERFUSION; CORONARY ARTERY DISEASE; DIPYRIDAMOLE; DIAGNOSTIC ACCURACY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
D.D. Miller et al., "DIAGNOSTIC-ACCURACY OF DIPYRIDAMOLE TECHNETIUM 99M-LABELED SESTAMIBI MYOCARDIAL TOMOGRAPHY FOR DETECTION OF CORONARY-ARTERY DISEASE", Journal of nuclear cardiology, 4(1), 1997, pp. 18-24

Abstract

Background. The diagnostic accuracy of exercise Tc-99m-labeled sestamibi and intravenous dipyridamole Tl-201-labeled myocardial tomography is established, The accuracy of dipyridamole stress Tc-99m-labeled sestamibi myocardial tomography for the detection of coronary artery disease has not been reported. Methods and Results. Our purpose was to determine the diagnostic accuracy of same-day, rest-dipyridamole stress Tc-99m-labeled sestamibi myocardial single-photon emission computed tomography (SPECT) compared with coronary angiography, Two hundred forty-four patients who were unable to exercise adequately underwent both dipyridamole Tc-99m-labeled sestamibi SPECT and coronary angiography within 6 months, Dipyridamole was administered intravenously in a standard dose of 0.56 mg/kg for 4 minutes. Cardiac and noncardiac side effects were recorded, The presence of coronary stenoses of 50% or greater diameter reduction in each of the major coronary arteries was compared with imaging data in corresponding myocardial perfusion beds, The patient population was predominately (98.8%) male with a mean age of 63 +/- 9 years (range 33 to 83 years), The majority of patients had stable angina (88%). Eighty-four patients (35%) gave a prior history of myocardial infarction; 44 patients (18%) had a history of congestire heart failure. The principal limitation to exercise stress was peripheral vascular disease in 62 patients (26%), No serious side effects occurred during dipyridamole stress; 14% of patients had chest pain and 8% of patients had 1 mm or greater ST segment depression, Of the 204 patientswith documented coronary stenoses, 43 (21%) had single-vessel diseaseand 161 (79%) had multivessel disease, The sensitivity was 93% (40/43in patients with single-vessel disease) and 91% (146/161 in patients with multivessel disease), Overall sensitivity was 91%. The specificity was 28% (11/40) in this population with a high prestest probability of coronary artery disease and posttest referral for cardiac catheterization. Conclusion. Tc-99m-labeled sestamibi myocardial tomography in conjunction with intravenous dipyridamole stress is a safe and sensitive method for the detection of coronary artery disease, The diagnosticaccuracy of dipyridamole stress Tc-99m-labeled sestamibi SPECT for the detection of coronary artery disease is similar to that reported forexercise stress Tc-99m-labeled sestamibi tomography, making this a suitable alternative for the evaluation of patients who are unable to exercise adequately.

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Documento generato il 30/03/20 alle ore 19:41:15