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Titolo:
PREVALENCE OF SUBCLINICAL ATHEROSCLEROSIS AND CARDIOVASCULAR-DISEASE AND ASSOCIATION WITH RISK-FACTORS IN THE CARDIOVASCULAR HEALTH STUDY
Autore:
KULLER L; BORHANI N; FURBERG C; GARDIN J; MANOLIO T; OLEARY D; PSATY B; ROBBINS J;
Indirizzi:
UNIV PITTSBURGH,GRAD SCH PUBL HLTH,DEPT EPIDEMIOL,130 DESOTO ST PITTSBURGH PA 15261 CARDIOVASC HLTH STUDY COORDINATING CTR SEATTLE WA 00000 BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEM NC 00000 UNIV CALIF IRVINE,IRVINE MED CTR ORANGE CA 92668 NHLBI BETHESDA MD 20892 GEISINGER MED CTR DANVILLE PA 17822 CALIF STATE UNIV SACRAMENTO,CTR CARDIOVASC HLTH STUDY FIELD SACRAMENTO CA 95819
Titolo Testata:
American journal of epidemiology
fascicolo: 12, volume: 139, anno: 1994,
pagine: 1164 - 1179
SICI:
0002-9262(1994)139:12<1164:POSAAC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; HEART-DISEASE; CAROTID ATHEROSCLEROSIS; MYOCARDIAL-INFARCTION; OLDER; NECROPSY; PLAQUE; LIPIDS; MODE;
Keywords:
AGING; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASES; CAROTID ARTERY DISEASES; CORONARY DISEASE; RISK FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
L. Kuller et al., "PREVALENCE OF SUBCLINICAL ATHEROSCLEROSIS AND CARDIOVASCULAR-DISEASE AND ASSOCIATION WITH RISK-FACTORS IN THE CARDIOVASCULAR HEALTH STUDY", American journal of epidemiology, 139(12), 1994, pp. 1164-1179

Abstract

The prevalence of subclinical atherosclerosis and cardiovascular disease was evaluated among the 5,201 adults aged greater than or equal to65 years in four communities participating in the Cardiovascular Health Study from June 1989 through May 1990. A combined index based on electrocardiogram and echocardiogram abnormalities, carotid artery wall thickness and stenosis based on carotid ultrasound, decreased ankle-brachial blood pressure, and positive response to a Rose Questionnaire for angina or intermittent claudication defined subclinical disease. The prevalence of subclinical disease was 36% in women and 38.7% in men and increased with age. Among women, low-density lipoprotein cholesterol, systolic blood pressure, blood glucose, and cigarette smoking werepositively associated, and high-density lipoprotein cholesterol negatively associated, with subclinical disease. In men, systolic blood pressure, blood glucose, and cigarette smoking were independent risk factors in multiple logistic regression analyses. The risk factors for subclinical disease are, therefore, similar to those for clinical diseaseat younger ages, especially among women. It is possible that older individuals with subclinical disease are at very high risk of developingclinical disease and that more aggressive interventions to prevent clinical disease should be oriented to individuals with subclinical disease.

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Documento generato il 03/12/20 alle ore 16:04:33