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Titolo:
RAT RENAL INTERSTITIAL BRADYKININ, PROSTAGLANDIN E(2), AND CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE - EFFECTS OF ALTERED SODIUM-INTAKE
Autore:
SIRAGY HM; IBRAHIM MM; JAFFA AA; MAYFIELD R; MARGOLIUS HS;
Indirizzi:
UNIV VIRGINIA,HLTH SCI CTR,DEPT MED,BOX 482 CHARLOTTESVILLE VA 22908 UNIV VIRGINIA,HLTH SCI CTR,DEPT INTERNAL MED CHARLOTTESVILLE VA 22908 UNIV VIRGINIA,HLTH SCI CTR,DEPT PHARMACOL CHARLOTTESVILLE VA 22908 CAIRO UNIV CAIRO EGYPT MED UNIV S CAROLINA CHARLESTON SC 00000
Titolo Testata:
Hypertension
fascicolo: 6, volume: 23, anno: 1994,
parte:, 2
pagine: 1068 - 1070
SICI:
0194-911X(1994)23:6<1068:RRIBPE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE RADIOIMMUNOASSAY; ARACHIDONIC-ACID; LOCALIZATION; STIMULATION; KALLIKREIN; NEPHRON; BINDING; KININS; PLAYS;
Keywords:
BRADYKININ; EXTRACELLULAR SPACE; SODIUM; DINOPROSTONE; GUANOSINE CYCLIC MONOPHOSPHATE; KIDNEY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
H.M. Siragy et al., "RAT RENAL INTERSTITIAL BRADYKININ, PROSTAGLANDIN E(2), AND CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE - EFFECTS OF ALTERED SODIUM-INTAKE", Hypertension, 23(6), 1994, pp. 1068-1070

Abstract

Kinins generated intrarenally probably affect renal function by altering levels of various mediators and messengers, including prostaglandin E(2) (PGE(2)) and cyclic guanosine 3',5'-monophosphate (cGMP). Usinga microdialysis technique, we monitored levels of cortical and medullary renal interstitial fluid kinins, PGE(2), and cGMP after 5 days of 0.15% (low), 0.28% (normal), or 4.0% (high) sodium intake. Samples were collected from anesthetized rats (n = 5 for each diet). During normal sodium intake, renal interstitial fluid kinin, PGE(2), and cGMP levels in dialysate leaving the cortex were 113+/-8 pg/min, 1.23+/-0.11 pg/min, and 0.05+/-0.004 pmol/min, respectively. In the fluid leaving the medulla, the levels were 93.0+/-17 pg/min, 2.28+/-0.14 pg/min, and 0.08+/-0.005 pmol/min, respectively. In rats consuming a low sodium diet, renal cortical interstitial fluid kinin and cortical and medullary PGE2( )and cGMP appearance rates were significantly increased (P<.01). Rats consuming a high sodium diet showed renal cortical and medullarykinin levels that were decreased 100-fold (P<.01), whereas PGE(2) andcGMP were increased (P<.01) compared with levels in rats with normal sodium intake. Renal interstitial fluid kinin is extremely sensitive to dietary sodium, but changes in interstitial fluid PGE(2) and cGMP are not always directionally similar, suggesting different regulations of these substances in response to sodium intake.

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Documento generato il 05/07/20 alle ore 12:51:14