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Titolo:
BETA-ADRENERGIC BLOCKING TREATMENT AND 24-HOUR BAROREFLEX SENSITIVITYIN ESSENTIAL HYPERTENSIVE PATIENTS
Autore:
PARATI G; MUTTI E; FRATTOLA A; CASTIGLIONI P; DIRIENZO M; MANCIA G;
Indirizzi:
UNIV MILAN,OSPED S LUCA,CTR AUXOL ITALIANO,IST SCI,VIA SPAGNOLETTO 3 I-2014 MILAN ITALY UNIV MILAN,MED & MED INTERNA CLIN 1 MILAN ITALY S GERARDO HOSP MONZA ITALY FDN PRO JUVENTUTE,CTR BIOINGN MILAN ITALY
Titolo Testata:
Hypertension
fascicolo: 6, volume: 23, anno: 1994,
parte:, 2
pagine: 992 - 996
SICI:
0194-911X(1994)23:6<992:BBTA2B>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL BLOOD-PRESSURE; BARORECEPTOR REFLEX; AUTONOMIC REGULATION; PROPRANOLOL; ANTAGONISTS; HUMANS;
Keywords:
RECEPTORS, ADRENERGIC, BETA; PRESSORECEPTORS; SEQUENCE ANALYSIS; BLOOD PRESSURE MONITORS; BLOOD PRESSURE; HYPERTENSION, ESSENTIAL; HEART RATE; SPECTRAL ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
G. Parati et al., "BETA-ADRENERGIC BLOCKING TREATMENT AND 24-HOUR BAROREFLEX SENSITIVITYIN ESSENTIAL HYPERTENSIVE PATIENTS", Hypertension, 23(6), 1994, pp. 992-996

Abstract

We dynamically evaluated the effects of beta-blockade on the sensitivity of arterial baroreflex control of heart rate in 10 mild or moderate essential hypertensive patients in whom blood pressure was recorded intra-arterially for 24 hours in ambulatory conditions. Twenty-four-hour baroreflex sensitivity was assessed by both (1) a time-domain approach based on the calculation of the slope of the regression line between linearly related progressive increases in systolic blood pressure and pulse interval (+PI/+SBP sequences) and decreases in systolic bloodpressure and pulse interval (-PI/-SBP sequences) and (2) a frequency-domain approach, ie, the ratio between the spectral powers of pulse interval and systolic blood pressure around 0.1 Hz (alpha coefficient). Data were obtained before and after 1 month of administration of either acebutolol (n=5) or labetalol (n=5). Before treatment, the 24-hour average slopes of the +PI/+SBP and -PI/-SBP sequences were 4.36 +/- 0.32 and 4.05 +/- 0.27 ms/mm Hg, respectively, while the alpha coefficient was 7.78 +/- 0.7 ms/mm Hg. After beta-blockade, these values were increased by 25.3 +/- 6.8%, 25.0 +/- 8.0%, and 32.1 +/- 9.3%, respectively (P<.01 for all values). Thus, beta-blockers potentiate baroreflex sensitivity in daily life. Time-domain and frequency-domain methods yielded superimposable results in dynamically evaluating 24-hour baroreflex sensitivity and its changes after beta-blockade.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:27:27