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Titolo:
NEUROTROPHIN-4 SELECTIVELY PROMOTES SURVIVAL OF STRIATAL NEURONS IN ORGANOTYPIC SLICE CULTURE
Autore:
ARDELT AA; FLARIS NA; ROTH KA;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PATHOL,BOX 8118 ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PATHOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT MOLEC BIOL & PHARMACOL ST LOUIS MO 63110
Titolo Testata:
Brain research
fascicolo: 2, volume: 647, anno: 1994,
pagine: 340 - 344
SICI:
0006-8993(1994)647:2<340:NSPSOS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; FACTOR FAMILY; RAT STRIATUM; TRK FAMILY; RECEPTORS; CELLS; EXPRESSION; NGF; MEMBERS; TISSUE;
Keywords:
NEUROTROPHIC EFFECT; BASAL GANGLIA; HUNTINGTONS DISEASE; EXPLANT CULTURE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Ardelt et al., "NEUROTROPHIN-4 SELECTIVELY PROMOTES SURVIVAL OF STRIATAL NEURONS IN ORGANOTYPIC SLICE CULTURE", Brain research, 647(2), 1994, pp. 340-344

Abstract

The neurotrophins (NGF, BDNF, NT-3, and NT-4) provide trophic supportto subpopulations of neurons in the central and peripheral nervous systems. We examined organotypic slices of neonatal mouse striatum maintained in medium supplemented with neurotrophins or with CNTF to determine which of these factors influence the survivability of striatal neurons. Neuron counts at the end of the culture period revealed that NT-4 was the only factor that had a significant effect on neuronal survival, suggesting that NT-4 is a trophic factor for striatal neurons in organotypic slices.

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Documento generato il 13/07/20 alle ore 17:21:23