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Titolo:
SOLUBLE TNF RECEPTORS (TNF-SR(55) AND TNF-SR(75)) IN LUNG ALLOGRAFT RECIPIENTS DISPLAYING CYTOMEGALOVIRUS PNEUMONITIS
Autore:
HUMBERT M; ROUXLOMBARD P; CERRINA J; MAGNAN A; SIMONNEAU C; DARTEVELLE P; GALANAUD P; DAYER JM; EMILIE D;
Indirizzi:
INSERM,U131,IMMUNOPATHOL & IMMUNOL VIRALE LAB,32 RUE CARNETS F-92140 CLAMART FRANCE HOP ANTOINE BECLERE,SERV PNEUMOL CLAMART FRANCE CTR CHIRURG MARIE LANNELONGUE,SERV CHIRURG THORAC & TRANSPLANTAT PULMF-92350 LE PLESSIS ROBINS FRANCE UNIV GENEVA,HOP CANTONAL,DIV IMMUNOL & ALLERGY CH-1211 GENEVA SWITZERLAND
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 6, volume: 149, anno: 1994,
pagine: 1681 - 1685
SICI:
1073-449X(1994)149:6<1681:STR(AT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; RESPIRATORY-DISTRESS SYNDROME; FACTOR-ALPHA; I TNF; TRANSPLANTATION; SERUM; SHOCK; INTERLEUKIN-1; REJECTION; CACHECTIN;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M. Humbert et al., "SOLUBLE TNF RECEPTORS (TNF-SR(55) AND TNF-SR(75)) IN LUNG ALLOGRAFT RECIPIENTS DISPLAYING CYTOMEGALOVIRUS PNEUMONITIS", American journal of respiratory and critical care medicine, 149(6), 1994, pp. 1681-1685

Abstract

Two distinct types of tu mor necrosis factor receptors (TNF-R) have been identified (TNF-R(55) and TNF-R(75)). Both TNF-R also exist in soluble forms (TNF-sR), resulting from the release of the extracellular domains (TNF-sR(55) and TNFsR(75)), TNF-sR may play an important role in vivo as they can bind to TNF alpha and prevent ligand binding to thecellular TNF-R, thus acting as naturally occurring inhibitors of TNF alpha. Sera from lung allograft recipients with cytomegalovirus (CMV) pneumonitis (12 patients) were assayed for TNF-sR(55) and TNFsR(75). The concentrations were compared with those from either control lung recipients displaying neither rejection nor infection (12 patients), or lung recipients with allograft rejection (12 patients). Serum TNF-sR(55) and TNF-sR(75) concentrations were measured by enzyme-linked immunologic binding assay. Serum TNF-sR(55) and TNF-sR(75) concentrations were significantly higher during CMV pneumonitis (mean +/- SEM: 13.7 +/-4.7 ng/ml, and 11.7 +/- 2.7 ng/ml, respectively) than during allograft rejection (3.7 +/- 0.3 ng/ml, p < 0.001, and 2.6 +/- 0.6 ng/ml, p < 0.001, respectively). They were also higher than in control subjects (3.6 +/- 0.3 ng/ml, p < 0.001, and 1.9 +/- 0.5 ng/ml, p < 0.001, respectively). Serum TNF alpha concentration was low in case of rejection orin control subjects (< 20 pg/ml). Conversely increased levels of TNF alpha were detected in the serum of six out of the 12 patients with CMV pneumonitis (p < 0.03 versus rejection and control subjects). Ganciclovir treatment of CMV pneumonitis led to a dramatic decrease of TNF alpha, TNFsR(55), and TNF-sR(75) serum levels. This report demonstratesthat there are high levels of TNF-sR in the serum of lung recipients displaying CMV pneumonitis, suggesting a possible mechanism for modulation of excessive macrophage activation arising in response to symptomatic CMV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:28:01