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Titolo:
EFFECTS OF MECHANICAL VENTILATION ON DIAPHRAGMATIC CONTRACTILE PROPERTIES IN RATS
Autore:
LEBOURDELLES G; VIIRES N; BOCZKOWSKI J; SETA N; PAVLOVIC D; AUBIER M;
Indirizzi:
HOP BICHAT,8 EME SUD,46 RUE HENRI HUCHARD F-75018 PARIS FRANCE FAC XAVIER BICHAT,INSERM,U226,PATHOL EXPTL LAB F-75018 PARIS FRANCE
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 6, volume: 149, anno: 1994,
pagine: 1539 - 1544
SICI:
1073-449X(1994)149:6<1539:EOMVOD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE; LIMB IMMOBILIZATION; HINDLIMB SUSPENSION; PRESSURE; FATIGUE; DISUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
G. Lebourdelles et al., "EFFECTS OF MECHANICAL VENTILATION ON DIAPHRAGMATIC CONTRACTILE PROPERTIES IN RATS", American journal of respiratory and critical care medicine, 149(6), 1994, pp. 1539-1544

Abstract

We measured in rats the effects of 48 h of mechanical ventilation on the weight, contractile properties, and enzymatic profile of the diaphragm, the soleus and the extensor digitorium longus (EDL) muscles. Eighteen animals were randomly divided into a mechanically ventilated (MV, n = 9) group or a control (C, n = 9) group. During the 48 h of mechanical ventilation, animals in the MV group were anesthetized with sodium thiopental and enterally fed with a gastric catheter. Group C animals were neither anesthetized nor mechanically ventilated during the 48-h experimental period, and they had access to food and water ad libitum. Muscular contractile properties were measured in vitro by analysisof force-frequency curves and twitch characteristics. The weights of the three muscles were significantly reduced in the MV group compared with those in the C group. This was accompanied in the diaphragm by a reduction in the normalized force generated for all the frequencies ofstimulation, except 20 Hz, whereas twitch characteristics were not modified. The forces generated by the soleus and EDL were not significantly reduced in the MV group compared with those in the C group. Diaphragm, soleus, and EDL citrate synthase and lactate dehydrogenase activities were not significantly different in the two groups. We conclude that mechanical ventilation for 48 h in rats produces a selective forcereduction in the diaphragm.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:50:25