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Titolo:
CD11B CD18 EXPRESSION, ADHERENCE, AND CHEMOTAXIS OF GRANULOCYTES IN ADULT-RESPIRATORY-DISTRESS-SYNDROME/
Autore:
LAURENT T; MARKERT M; VONFLIEDNER V; FEIHL F; SCHALLER MD; TAGAN MC; CHIOLERO R; PERRET C;
Indirizzi:
CHU VAUDOIS,DEPT MED,INTENS CARE UNIT,BH-10 CH-1011 LAUSANNE SWITZERLAND CHU VAUDOIS,LUDWIG INST CANC RES,INST PHYSIOPATHOL CLIN,CENT CHIM CLIN LAB LAUSANNE SWITZERLAND
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 6, volume: 149, anno: 1994,
pagine: 1534 - 1538
SICI:
1073-449X(1994)149:6<1534:CCEAAC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMORPHONUCLEAR NEUTROPHILS; ADHESION MOLECULES; SURFACE EXPRESSION; METABOLIC-ACTIVITY; LEUKOCYTES; RECEPTORS; PULMONARY; INJURY; ENDOTHELIUM; PREVENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
T. Laurent et al., "CD11B CD18 EXPRESSION, ADHERENCE, AND CHEMOTAXIS OF GRANULOCYTES IN ADULT-RESPIRATORY-DISTRESS-SYNDROME/", American journal of respiratory and critical care medicine, 149(6), 1994, pp. 1534-1538

Abstract

The accumulation of granulocytes in the pulmonary microvasculature isgenerally thought a cardinal event in the pathology of adult respiratory distress syndrome (ARDS). However, the mechanism by which granulocytes are sequestered in the pulmonary vascular bed remains largely unknown. Because the CD11b/ CD18 membrane receptors mediate various adhesion-dependent functions, their expression was investigated in granulocytes from patients during the course of ARDS development in relation to adherence and chemotaxis. CD11b expression of ARDS resting granulocytes was increased within 24 h of ARDS onset by a factor of two in comparison with control patients (p < 0.05) and remained significantly increased 72 to 120 h later. In contrast, the stimulated expression was significantly decreased only within 24 h of ARDS onset. Adherence was not modified within 8 h of the onset of ARDS, but was increased at Days1, 3, and 5. The time course of granulocyte chemotaxis shows a decreased chemotaxis capacity during the first 3 d of ARDS, followed by normalization at Day 5. The dynamic changes observed in the various functions studied indicate a possible relationship between the modulation ofthe CD11b expression and a hyperadhesive state of granulocytes in ARDS. These sticky granulocytes may potentially contribute to the microvascular injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:06:09