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Titolo:
THE AGE DEPENDENCY OF GENE-EXPRESSION FOR PLASMA-LIPIDS, LIPOPROTEINS, AND APOLIPOPROTEINS
Autore:
SNIEDER H; VANDOORNEN LJP; BOOMSMA DI;
Indirizzi:
ST THOMAS HOSP,TWIN RES UNIT,LAMBETH PALACE RD LONDON SE1 7EH ENGLAND VRIJE UNIV AMSTERDAM,DEPT PSYCHOPHYSIOL AMSTERDAM NETHERLANDS
Titolo Testata:
American journal of human genetics
fascicolo: 3, volume: 60, anno: 1997,
pagine: 638 - 650
SICI:
0002-9297(1997)60:3<638:TADOGF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-HEART-DISEASE; RISK FACTOR VARIABLES; CARDIOVASCULAR-DISEASE; CHOLESTEROL LEVELS; A-I; TWINS; HERITABILITY; ATHEROSCLEROSIS; PHENOTYPES; POPULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
H. Snieder et al., "THE AGE DEPENDENCY OF GENE-EXPRESSION FOR PLASMA-LIPIDS, LIPOPROTEINS, AND APOLIPOPROTEINS", American journal of human genetics, 60(3), 1997, pp. 638-650

Abstract

The aim of this study was to investigate and disentangle the genetic and nongenetic causes of stability and change in lipids and (apo)lipoproteins that occur during the lifespan. Total cholesterol, low-densitylipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, apolipoprotein Al (ApoA1), apolipoprotein B (ApoB), and lipoprotein(a) (Lp[a]) were measured in a group of 160 middle-aged parents and their twin offspring (first project) and in a group of 203 middle-aged twin pairs (second project). Combining the data of both projects enabled the estimation of the extent to which measured lipid parameters are influenced by different genes in adolescence and adulthood. To that end, an extended quantitative genetic model was specified, which allowed the estimation of heritabilities for each sex and generation separately. Heritabilities were similar for both sexes and both generations. Larger variances in the parental generation could be ascribed to proportionalincreases in both unique environmental and additive genetic variance from childhood to adulthood, which led to similar heritability estimates in adolescent and middle-aged twins. Although the magnitudes of heritabilities were similar across generations, results showed that, for total cholesterol, triglycerides, HDL, and LDL, partly different genesare expressed in adolescence compared to adulthood. For triglycerides, only 46% of the genetic variance was common to both age groups; for total cholesterol this was 80%. Intermediate values were found for HDL(66%) and LDL (76%). For ApoA1, ApoB, and Lp(a), the same genes seem to act in both generations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:49:40