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Titolo:
PREVENTION OF SPOROGONY OF PLASMODIUM-FALCIPARUM AND P-BERGHEI IN ANOPHELES-STEPHENSI MOSQUITOS BY TRANSMISSION-BLOCKING ANTIMALARIALS
Autore:
COLEMAN RE; NATH AK; SCHNEIDER I; SONG GH; KLEIN TA; MILHOUS WK;
Indirizzi:
USA,MED RES INST INFECT DIS,DEPT EPIDEMIOL,DIV APPL RES FREDERICK MD 21702 WALTER REED ARMY INST RES,DEPT PARASITOL WASHINGTON DC 00000 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL WASHINGTON DC 20307 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT PARASITOL WASHINGTON DC 20307
Titolo Testata:
The American journal of tropical medicine and hygiene
fascicolo: 5, volume: 50, anno: 1994,
pagine: 646 - 653
SICI:
0002-9637(1994)50:5<646:POSOPA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPORONTOCIDAL ACTIVITY; MALARIA; INVITRO; DRUG; ANKA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
R.E. Coleman et al., "PREVENTION OF SPOROGONY OF PLASMODIUM-FALCIPARUM AND P-BERGHEI IN ANOPHELES-STEPHENSI MOSQUITOS BY TRANSMISSION-BLOCKING ANTIMALARIALS", The American journal of tropical medicine and hygiene, 50(5), 1994, pp. 646-653

Abstract

The sporontocidal activity of three 8-aminoquinolines, a 1,4-naphthoquinone, and three dihydroacridine-diones was determined against the ANKA clone of Plasmodium berghei and both chloroquine-sensitive (NF54) and chloroquine-resistant (7G8) P. falciparum. Anopheles stephensi mosquitoes previously fed on P. berghei-infected mice or P. falciparum-infected cultures were refed on uninfected mice treated previously with agiven drug. Sporontocidal activity was determined by assessing both oocyst and sporozoite development. Neither primaquine nor menoctone exhibited sporontocidal activity against P. berghei or either strain of P. falciparum at a dose of 100 mg base drug/kg mouse body weight, whereas the other five compounds each effectively interrupted the sporogonic development of all three parasite strains at this dose. These data clearly demonstrate that experimental dihydroacridine-diones and 8-aminoquinolines are capable of interrupting the sporogonic development of P. berghei and chloroquine-sensitive and chloroquine-resistant P. falciparum. These data also suggest that the P. berghei model may be used to accurately predict sporontocidal activity against P. falciparum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 00:43:50