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Titolo:
NMR-STUDY OF THE INCLUSION COMPLEX FORMED BETWEEN GAMMA-CYCLODEXTRIN AND TMDOTP5-
Autore:
SHERRY AD; ZARZYCKI R; GERALDES CFGC;
Indirizzi:
UNIV TEXAS,DEPT CHEM,POB 830688 RICHARDSON TX 75083 UNIV TEXAS,SW MED CTR,MARY NELL & RALPH B ROGERS MAGNET RESONANCE CTR,DEPT RADIOL DALLAS TX 75235
Titolo Testata:
Magnetic resonance in chemistry
fascicolo: 6, volume: 32, anno: 1994,
pagine: 361 - 365
SICI:
0749-1581(1994)32:6<361:NOTICF>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NA-23 SHIFT-REAGENT; PERFUSED RAT-HEART; INTRACELLULAR SODIUM; CONTRAST AGENTS; CRYSTAL;
Keywords:
LANTHANIDE-INDUCED NMR SHIFTS; H-1 NMR; HOST-GUEST COMPLEX; GAMMA-CYCLODEXTRIN-PARAMAGNETIC ANION COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
A.D. Sherry et al., "NMR-STUDY OF THE INCLUSION COMPLEX FORMED BETWEEN GAMMA-CYCLODEXTRIN AND TMDOTP5-", Magnetic resonance in chemistry, 32(6), 1994, pp. 361-365

Abstract

The host-guest complex formed in aqueous solution between gamma-cyclodextrin (gamma-CD) and the macrocyclic paramagnetic shift reagent TmDOTP5- was examined by NMR spectroscopy. Paramagnetic lanthanide-inducedshifts (LIS) and spin-lattice relaxation rate enhancements in the proton resonances of gamma-CD on binding of TmDOTP5- were used to define the position of the guest anion within the host cavity. A proportionality constant which relates pseudo-contact shifts induced by TmDOTP5- to the geometrical position of each ligand nucleus (previously determined from a LIS study of the TmDOTP5- complex) was used to determine a fully bound EIS value for each gamma-CD proton. These values, in combination with experimental LIS data from TmDOTP5- titrations at constant gamma-CD concentration, were then used to obtain the association constant For the host-guest complex (3.9-4.5 mol l(-1)). These constants were indicative of a weak host-guest interaction and consistent with thelocation of the TmDOTP5- binding site reported by the LIS values wellabove the center of the gamma-CD cavity.

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Documento generato il 28/11/20 alle ore 09:24:26