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Titolo:
DOBUTAMINE TC-99M-MIBI SINGLE-PHOTON EMISSION TOMOGRAPHY - NON-EXERCISE-DEPENDENT DETECTION OF HEMODYNAMICALLY SIGNIFICANT CORONARY-ARTERY STENOSES
Autore:
VOTH E; BAER FM; THEISSEN P; SCHNEIDER CA; SECHTEM U; SCHICHA H;
Indirizzi:
UNIV COLOGNE,NUKL MED KLIN & POLIKLIN,JOSEPH STELZMANN STR 9 D-50924 COLOGNE GERMANY UNIV COLOGNE,INNERE MED KLIN 3 D-50924 COLOGNE GERMANY
Titolo Testata:
European journal of nuclear medicine
fascicolo: 6, volume: 21, anno: 1994,
pagine: 537 - 544
SICI:
0340-6997(1994)21:6<537:DTSET->2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHOXY ISOBUTYL ISONITRILE; HIGH-DOSE DIPYRIDAMOLE; ACUTE MYOCARDIAL-INFARCTION; BLOOD-FLOW; STRESS ECHOCARDIOGRAPHY; COMPUTED-TOMOGRAPHY; DISEASE; TL-201; SCINTIGRAPHY; INFUSION;
Keywords:
CORONARY ARTERY DISEASE; TC-99M METHOXYISOBUTYLISONITRILE SINGLE-PHOTON EMISSION TOMOGRAPHY; DOBUTAMINE; CORONARY ANGIOGRAPHY; EXERCISE STRESS TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
E. Voth et al., "DOBUTAMINE TC-99M-MIBI SINGLE-PHOTON EMISSION TOMOGRAPHY - NON-EXERCISE-DEPENDENT DETECTION OF HEMODYNAMICALLY SIGNIFICANT CORONARY-ARTERY STENOSES", European journal of nuclear medicine, 21(6), 1994, pp. 537-544

Abstract

Dobutamine pharmacological stress testing in conjunction with technetium-99m methoxyisobutylisonitrile single-photon emission tomography (MIBI SPET) may be a useful alternative to convential exercise stress MIBI SPET for the detection and localisation of coronary artery stenoses. Therefore, 35 patients with stenoses (greater-than-or-equal-to 50% diameter reduction) of one or more coronary arteries were selected for dobutamine MIBI SPET. Each patient underwent MIBI injection at rest and during dobutamine infusion with incremental doses (5, 10, 15 and 20 mug kg-1 min-1). A conventional exercise stress test (EST) was performed in all patients. Peak double product during steady-state dobutamineinfusion (18 200 +/- 4200 mmHg min-1) was lower (P = 0.0001) than during EST (21 700 +/- 4900 mmHg min-1). Image quality was good in all but one patient, who had to be excluded from data analysis due to excessive hepatobiliary MIBI activity. Dobutamine-induced perfusion abnormalities were observed in 30/34 MIBI SPET studies, resulting in an overall detection rate for coronary artery disease of 88%. A pathological EST was observed in 23134 patients (68%). The detection rate of individual coronary artery stenoses was 85% (28/33) for stenosess with a severe diameter reduction (> 70%) and 50% (12/24) for stenoses with a moderate diameter reduction (greater-than-or-equal-to 50-70%). In particular, sensitivity and specificity for the detection of moderate and severe stenoses (greater-than-or-equal-to 50%) were 75%/100% for left anterior descending, 67%/95% for left circumflex and 67%/69% for right coronary artery stenoses. Dobutamine MIBI SPET is a well-tolerated, non-exercise-dependent test for detection and localisation of haemodynamically significant coronary artery stenoses. The use of dobutamine allows a stepwise increase in pharmacological stress similar to EST and is especially useful in patients who are unable to exercise.

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Documento generato il 25/11/20 alle ore 10:14:33