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Titolo:
SECRETION OF ALPHA-1-ANTITRYPSIN BY ALVEOLAR EPITHELIAL-CELLS
Autore:
VENEMBRE P; BOUTTEN A; SETA N; DEHOUX MS; CRESTANI B; AUBIER M; DURAND G;
Indirizzi:
HOP BICHAT,SERV BIOCHIM A,46 HENRI HUCHARD F-75877 PARIS 18 FRANCE HOP BICHAT,INSERM,U408 F-75877 PARIS 18 FRANCE
Titolo Testata:
FEBS letters
fascicolo: 2-3, volume: 346, anno: 1994,
pagine: 171 - 174
SICI:
0014-5793(1994)346:2-3<171:SOABAE>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-1-PROTEINASE INHIBITOR; HUMAN-MONOCYTES; GENE; MACROPHAGES; EXPRESSION; NITROCELLULOSE; LINE; RNA;
Keywords:
GLYCOSYLATION; A549 CELL LINE; TYPE-II PNEUMOCYTE; HUMAN; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
P. Venembre et al., "SECRETION OF ALPHA-1-ANTITRYPSIN BY ALVEOLAR EPITHELIAL-CELLS", FEBS letters, 346(2-3), 1994, pp. 171-174

Abstract

We have investigated the ability of alveolar epithelial cells (human A549 cell line and rat type-II pneumocytes) to produce al-antitrypsin (AAT). Northern blot analysis demonstrated the presence of an AAT-specific mRNA transcript in A549 cells. Unstimulated A549 cells secreted immunoreactive AAT at a rate of 0.51 +/- 0.04 ng/10(6) cells/h, with a modified glycosylation compared to serum AAT. AAT formed a complex with neutrophil elastase. Rat type-II pneumocytes secreted immunoreactiveAAT. Our results suggest that alveolar epithelial cells could participate in antiprotease defense within the lung through local AAT production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:52:30