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Titolo: SECRETION OF ALPHA-1-ANTITRYPSIN BY ALVEOLAR EPITHELIAL-CELLS
Autore: VENEMBRE P; BOUTTEN A; SETA N; DEHOUX MS; CRESTANI B; AUBIER M; DURAND G;
- Indirizzi:
- HOP BICHAT,SERV BIOCHIM A,46 HENRI HUCHARD F-75877 PARIS 18 FRANCE HOP BICHAT,INSERM,U408 F-75877 PARIS 18 FRANCE
- Titolo Testata:
- FEBS letters
fascicolo: 2-3,
volume: 346,
anno: 1994,
pagine: 171 - 174
- SICI:
- 0014-5793(1994)346:2-3<171:SOABAE>2.0.ZU;2-S
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- ALPHA-1-PROTEINASE INHIBITOR; HUMAN-MONOCYTES; GENE; MACROPHAGES; EXPRESSION; NITROCELLULOSE; LINE; RNA;
- Keywords:
- GLYCOSYLATION; A549 CELL LINE; TYPE-II PNEUMOCYTE; HUMAN; RAT;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Science Citation Index Expanded
- Citazioni:
- 26
- Recensione:
- Indirizzi per estratti:
-
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- Citazione:
- P. Venembre et al., "SECRETION OF ALPHA-1-ANTITRYPSIN BY ALVEOLAR EPITHELIAL-CELLS", FEBS letters, 346(2-3), 1994, pp. 171-174
Abstract
We have investigated the ability of alveolar epithelial cells (human A549 cell line and rat type-II pneumocytes) to produce al-antitrypsin (AAT). Northern blot analysis demonstrated the presence of an AAT-specific mRNA transcript in A549 cells. Unstimulated A549 cells secreted immunoreactive AAT at a rate of 0.51 +/- 0.04 ng/10(6) cells/h, with a modified glycosylation compared to serum AAT. AAT formed a complex with neutrophil elastase. Rat type-II pneumocytes secreted immunoreactiveAAT. Our results suggest that alveolar epithelial cells could participate in antiprotease defense within the lung through local AAT production.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:52:30