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Titolo:
MASSETER MUSCLE RIGIDITY AND MALIGNANT HYPERTHERMIA SUSCEPTIBILITY INPEDIATRIC-PATIENTS - AN UPDATE ON MANAGEMENT AND DIAGNOSIS
Autore:
OFLYNN RP; SHUTACK JG; ROSENBERG H; FLETCHER JE;
Indirizzi:
HAHNEMANN UNIV,DEPT ANESTHESIOL,MAIL STOP 310,BROAD & VINE ST PHILADELPHIA PA 19102 HAHNEMANN UNIV,DEPT ANESTHESIOL PHILADELPHIA PA 19102
Titolo Testata:
Anesthesiology
fascicolo: 6, volume: 80, anno: 1994,
pagine: 1228 - 1233
SICI:
0003-3022(1994)80:6<1228:MMRAMH>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORTH-AMERICAN; HALOTHANE; SPASM; SUCCINYLCHOLINE; CAFFEINE; SWINE; HYPERPYREXIA; ANESTHESIA; PREDICTION; CHILDREN;
Keywords:
ANESTHETICS, VOLATILE, HALOTHANE; MALIGNANT HYPERTHERMIA, MASSETER MUSCLE RIGIDITY; NEUROMUSCULAR RELAXANT, SUCCINYLCHOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
R.P. Oflynn et al., "MASSETER MUSCLE RIGIDITY AND MALIGNANT HYPERTHERMIA SUSCEPTIBILITY INPEDIATRIC-PATIENTS - AN UPDATE ON MANAGEMENT AND DIAGNOSIS", Anesthesiology, 80(6), 1994, pp. 1228-1233

Abstract

Background: Controversy exists regarding the definition of masseter muscle rigidity (MMR) and anesthetic management after MMR. This study reports current anesthetic management after MMR, estimates the incidence of clinical malignant hyperthermia (MH) in patients with MMR, and isthe first to evaluate the coincidence of MMR with malignant hyperthermia susceptibility (MHS) according to the 1987 North American Malignant Hyperthermia Group protocol. Methods: Practicing anesthesiologists referred pediatric patients for biopsy between 1986 and 1991 based on evidence of MMR after succinylcholine (1975-1991). The clinical scenario was described as MMR alone or MMR followed by signs of MH, includingarterial CO, tension > 50 mmHg, arterial pH less than or equal to 7.25, and base deficit > 8. Patients had caffeine-halothane muscle contracture testing to determine MHS. Results: Seventy patients (50 boys and20 girls) were evaluated. Eighty-three percent (58 of 70) of anesthetics were halothane-succinylcholine. In 68% (48 of 70) of cases, the anesthetic was discontinued, whereas anesthesia was continued with nontriggering agents in 11% (8 of 70) and with triggering agents in 13% (9 of 70). Fifty-nine percent (41 of 70) of patients were diagnosed as MHS by muscle biopsy. In 7% (5 of 70) of patients, clinical MH developedwithin 10 min of MMR. Conclusions: This study, by using the current North American Malignant Hyperthermia Group protocol, reaffirms the high incidence (59%, 41 of 70) of MHS associated with MMR as confirmed bymuscle biopsy. Of the MHS patients, 5 developed signs of clinical MH. Most anesthesiologists in this study, when confronted with MMR, discontinued anesthesia. Because of the potential lethality of MH and the >50% concordance between MMR and MHS, the most conservative course of action after MMR is to discontinue the anesthetic and observe the patient for clinical evidence of MH. An acceptable alternative, depending on the urgency of the surgery, would be to continue anesthesia with nontriggering agents for MH, with appropriate monitoring.

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Documento generato il 19/01/20 alle ore 09:10:01