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Titolo:
NEGATIVE SEGREGATION OF MTV LOCI IN H-2E-RESPONSE( MICE SELECTED FOR HIGH ANTIBODY)
Autore:
ROGER T; BOUDALY S; SEMAN M;
Indirizzi:
UNIV PARIS 07,IMMUNODIFFERENCIAT LAB,BP 7124,2 PL JUSSIEU F-75251 PARIS 05 FRANCE
Titolo Testata:
Immunogenetics
fascicolo: 2, volume: 40, anno: 1994,
pagine: 123 - 128
SICI:
0093-7711(1994)40:2<123:NSOMLI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMARY-TUMOR VIRUS; T-CELL RECEPTOR; ANTIGEN RECEPTOR; SELF TOLERANCE; GENE USAGE; SUPERANTIGEN; RESPONSIVENESS; EXPRESSION; DELETION; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
T. Roger et al., "NEGATIVE SEGREGATION OF MTV LOCI IN H-2E-RESPONSE( MICE SELECTED FOR HIGH ANTIBODY)", Immunogenetics, 40(2), 1994, pp. 123-128

Abstract

Endogenous mouse mammary tumor proviruses (Mtvs) encode superantigens(Sags), which can delete T lymphocytes expressing particular Tcrb-V genes when associated with the H-2E molecule. In the present work, distribution of Mtvs was investigated in six independent pairs of mouse lines genetically selected for high (H) or low (L) Ab production to specific T-cell-dependent Ags. These experiments were performed to evaluate the role of Mtv-encoded Sags in the determination of H and L phenotypes. No systematic difference is observed in Mtv segregation between H-2E(-) H and L mouse lines. However, a clear differential segregation of Mtv loci is observed between H-2E(+) H and L mice from three independent selections. The number of endogenous Mtvs in L lines is close tothat found in laboratory mice. In constrast, Mtv loci-encoding Sags are almost absent in H animals. Although Sags profoundly affect the available Tcrb-V repertoire in H-2E(+) L mice, it seems unlikely that Mtvs account for the L phe notype which can be achieved independently of Mtv segregation in H-2E(-) lines. More importantly, the results suggest that negative segregation of Mtv-encoding Sags con tribute to determine the super-responder phenotype of H lines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:58:27