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Titolo:
THE ALPHA-3 CHAIN OF TYPE-IV COLLAGEN INDUCES AUTOIMMUNE GOODPASTURE-SYNDROME
Autore:
KALLURI R; GATTONE VH; NOELKEN ME; HUDSON BG;
Indirizzi:
UNIV KANSAS,MED CTR,DEPT BIOCHEM & MOLEC BIOL,39TH & RAINBOW BLVD KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT BIOCHEM & MOLEC BIOL KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT ANAT & CELL BIOL KANSAS CITY KS 66160
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 13, volume: 91, anno: 1994,
pagine: 6201 - 6205
SICI:
0027-8424(1994)91:13<6201:TACOTC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-BASEMENT-MEMBRANE; NONCOLLAGENOUS DOMAIN HEXAMER; NEPHRITOGENIC ANTIGEN; GLOMERULONEPHRITIS; IDENTIFICATION; LOCALIZATION; AUTOANTIBODIES; ORGANIZATION; NEPHRITIS; EPITOPE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
R. Kalluri et al., "THE ALPHA-3 CHAIN OF TYPE-IV COLLAGEN INDUCES AUTOIMMUNE GOODPASTURE-SYNDROME", Proceedings of the National Academy of Sciences of the United Statesof America, 91(13), 1994, pp. 6201-6205

Abstract

Human Goodpasture syndrome is a lethal form of autoimmune disease that is characterized by pulmonary hemorrhage and glomerulonephritis. Thetissue injury is mediated by autoantibodies that bind to glomerular and alveolar basement membrane. The target autoantigen is alpha 3(IV) collagen, one of six genetically distinct chains that comprise type IV collagen, and the epitope is sublocalized to the noncollagenous domain(NC1) of the alpha 3 chain. The present study reports the unique capacity of alpha 3(IV)NC1 dimer from bovine kidney to aberrantly engage the immune system of rabbits to respond to self, mimicking the organ-specific form of the human disease, whereas the other chains of type IV collagen are nonpathogenic. However, alpha 3(IV)NC1 hexamer was nonpathogenic, suggesting the exposure of a pathogenic epitope upon dissociation of hexamer into dimers. Exposure of the pathogenic epitope by infection or organic solvents, events which are thought to precede Goodpasture syndrome, may be the principal factor in the etiology of the disease. The pathogenicity of alpha 3(TV) collagen brings full circle a decade of research that has identified four novel chains (alpha 3-alpha6) of type IV collagen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:38:00