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Titolo:
INTERLEUKIN-1-BETA GENE-EXPRESSION IN EXPERIMENTAL GLOMERULONEPHRITISIN THE RAT - AN IN-SITU HYBRIDIZATION STUDY
Autore:
COOK HT; AVEY C; TAYLOR GM;
Indirizzi:
UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,ST MARYS HOSP,SCH MED,DEPT HISTOPATHOL,NORFOLK PL LONDON W2 1PG ENGLAND
Titolo Testata:
International journal of experimental pathology
fascicolo: 3, volume: 75, anno: 1994,
pagine: 157 - 163
SICI:
0959-9673(1994)75:3<157:IGIEG>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; GLOMERULAR MESANGIAL CELLS; IL-1; NEPHRITIS; LUPUS; MICE;
Keywords:
GLOMERULONEPHRITIS; INTERLEUKIN-1; IN-SITU HYBRIDIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
H.T. Cook et al., "INTERLEUKIN-1-BETA GENE-EXPRESSION IN EXPERIMENTAL GLOMERULONEPHRITISIN THE RAT - AN IN-SITU HYBRIDIZATION STUDY", International journal of experimental pathology, 75(3), 1994, pp. 157-163

Abstract

To investigate the role of interleukin-1 beta (IL-1 beta) in glomerulonephritis we studied the presence of IL-1 beta by in-situ hybridization in in-situ immune complex glomerulonephritis in the rat. Glomerulonephritis was induced in preimmunized rats by unilateral renal perfusion with cationized human IgG. In-situ hybridization was performed on frozen sections with a battery of four 30mer oligonucleotide DNA probes 3' end labelled with S-35-dATP. IL-1 beta mRNA was detectable in nephritic glomeruli at 6 and 24 hours after induction of glomerulonephritis. Signal was maximal at 48 hours and markedly reduced by 4 days. The peak of IL-1 beta transcription coincided with the major monocyte influx into glomeruli consistent with a role for IL-1 beta as a mediator ofglomerular hypercellularity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 18:26:26