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Titolo:
MOLECULAR PHYSIOLOGY OF AMYLIN
Autore:
PITTNER RA; ALBRANDT K; BEAUMONT K; GAETA LSL; KODA JE; MOORE CX; RITTENHOUSE J; RINK TJ;
Indirizzi:
AMYLIN PHARMACEUT INC,9373 TOWNE CTR DR SAN DIEGO CA 92121 AMYLIN PHARMACEUT INC SAN DIEGO CA 92121
Titolo Testata:
Journal of cellular biochemistry
, volume: 55, anno: 1994, supplemento:, S
pagine: 19 - 28
SICI:
0730-2312(1994)55:<19:MPOA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISLET AMYLOID POLYPEPTIDE; GENE-RELATED PEPTIDE; CALCITONIN-LIKE IMMUNOREACTIVITY; INVIVO INSULIN RESISTANCE; SKELETAL-MUSCLE INVITRO; LIVER PLASMA-MEMBRANES; PERFUSED RAT PANCREAS; CARCINOMA CELL-LINE; ADENYLATE-CYCLASE; SALMON-CALCITONIN;
Keywords:
AMYLIN; CALCITONIN; CGRP; CAMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
96
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Pittner et al., "MOLECULAR PHYSIOLOGY OF AMYLIN", Journal of cellular biochemistry, 55, 1994, pp. 19-28

Abstract

Amylin is a 37-amino acid peptide first isolated, purified, and characterized from the amyloid deposits in the pancreases of type 2 diabetics. It is synthesized and secreted primarily from pancreatic beta cells along with insulin. The ability of amylin to potently reduce insulin-stimulated incorporation of glucose into glycogen in skeletal muscle requires both an intact 2Cys-7Cys disulfide bond and a COOH-terminal amide. Amylin has structural and functional relationships to two other messenger proteins, calcitonin and CGRP. Amylin has relatively potent calcitonin-like activity on bone metabolism and weaker CGRP-like activity on the vasculature. CGRP is a slightly weaker agonist than amylin for metabolic responses. Although rat calcitonins are weak, teleost fish calcitonins are very potent agonists for amylin's metabolic effects. This group of peptides appears to act on a family of related G protein-coupled receptors; several variant calcitonin receptors have recently been cloned and expressed. These receptors appear to be coupled to adenylyl cyclase in many instances; recent evidence supports the view that amylin's effects on skeletal muscle occur, at least in large part, th rough activation of the cAMP pathway. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:43:16