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Titolo:
MOLECULAR CHARACTERIZATION OF A RECURRING COMPLEX CHROMOSOMAL TRANSLOCATION IN 2 HUMAN EXTRAGONADAL GERM-CELL TUMORS
Autore:
SINKE RJ; WEGHUIS DO; SUIJKERBUIJK RF; TANIGAMI A; NAKAMURA Y; LARSSON C; WEBER G; DEJONG B; OOSTERHUIS JW; MOLENAAR WM; VANKESSEL AG;
Indirizzi:
UNIV NIJMEGEN HOSP,DEPT HUMAN GENET,POB 9101 6500 HB NIJMEGEN NETHERLANDS CANC INST,DIV BIOCHEM TOKYO JAPAN KAROLINSKA INST,DEPT CLIN GENET STOCKHOLM SWEDEN UNIV GRONINGEN,DEPT HUMAN GENET & PATHOL GRONINGEN NETHERLANDS DR DANIEL DEN HOED CANC CTR ROTTERDAM NETHERLANDS
Titolo Testata:
Cancer genetics and cytogenetics
fascicolo: 1, volume: 73, anno: 1994,
pagine: 11 - 16
SICI:
0165-4608(1994)73:1<11:MCOARC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSITU HYBRIDIZATION; PHYSICAL MAP; MEN1 LOCUS; REGION; LOCALIZATION; IDENTIFICATION; ABERRATIONS; I(12P);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Sinke et al., "MOLECULAR CHARACTERIZATION OF A RECURRING COMPLEX CHROMOSOMAL TRANSLOCATION IN 2 HUMAN EXTRAGONADAL GERM-CELL TUMORS", Cancer genetics and cytogenetics, 73(1), 1994, pp. 11-16

Abstract

The molecular characterization of a recurring complex chromosomal translocation involving 6p21, 6p22, 6p23, and 11q13 in two independent bur similar extragonadal human germ cell rumors was initiated using fluorescence in situ hybridization (FISH) and pulse field gel electrophoresis (PFGE) techniques. By using a series of specific probes from the 11q13 region, the translocation breakpoint in this chromosomal band could be located within a long-range restriction enzyme map in between the markers D11S457 and D11S546. In addition, aberrantly hybridizing restriction fragments were revealed by PFGE in both tumors, indicating that the breakpoint region must be located within a distance of at maximum 200 kilobase pairs (kbp) from the nearest DNA marker (D11S546).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:04:09