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Titolo:
ENHANCEMENT OF RADIOIMMUNOTHERAPY BY DRUGS MODIFYING TUMOR BLOOD-FLOWIN A COLONIC XENOGRAFT MODEL
Autore:
PEDLEY RB; BEGENT RHJ; BODEN JA; BOXER GM; BODEN R; KEEP PA;
Indirizzi:
ROYAL FREE HOSP,SCH MED,DEPT CLIN ONCOL,CRC,TARGETING & IMAGING GRP LONDON NW3 2PF ENGLAND
Titolo Testata:
International journal of cancer
fascicolo: 6, volume: 57, anno: 1994,
pagine: 830 - 835
SICI:
0020-7136(1994)57:6<830:EORBDM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLAVONE ACETIC-ACID; ANTI-CEA ANTIBODIES; COLORECTAL-CARCINOMA; ANTITUMOR-ACTIVITY; NECROSIS-FACTOR; CELL-ACTIVITY; NSC-347512; CANCER; MICE; AGENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
R.B. Pedley et al., "ENHANCEMENT OF RADIOIMMUNOTHERAPY BY DRUGS MODIFYING TUMOR BLOOD-FLOWIN A COLONIC XENOGRAFT MODEL", International journal of cancer, 57(6), 1994, pp. 830-835

Abstract

Radioimmunotherapy (RIT) is hampered clinically by poor tumour localization of antibody. In order to enhance localization we have investigated the concomitant use of RIT with 2 drugs, flavone-8-acetic acid (FAA) and its analogue 5,6-dimethylxanthenone-4-acetic acid (XAA), which both reduce tumour blood flow and induce immunomodulation. A single i.v. does of 0.5 mCi (18.5 MBq) intact I-131 anti-CEA antibody significantly delayed growth and prolonged survival over that of untreated controls, in an established LS174T colon xenograft model in nude mice. Theadjuvant use of a single i.p. dose of either FAA or XAA, given 24 or 48 hr after I-131-A5B7 to allow maximum tumour levels of antibody to be attained before drug-induced blood-flow inhibition, significantly enhanced the RIT. FAA caused entrapment of antibody within the tumour inrelation to the time allowed for localization before drug administration. Repeated doses of FAA prolonged tumour growth inhibition but did not enhance the therapy achieved after a single dose. Although both drugs alone induced massive tumour necrosis of all but a thin peripheralrim of viable cells, tumour regrowth was inhibited for a few days only, with no effect on survival. Drug-induced tumour necrosis, immunomodulation and retention of higher doses of I-131-A5B7 within the tumour may contribute to the enhanced RIT produced by this combined therapy. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:50:35