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Titolo:
CHOLINERGIC INNERVATION IN THE HUMAN HIPPOCAMPAL-FORMATION INCLUDING THE ENTORHINAL CORTEX
Autore:
DELACALLE S; LIM C; SOBREVIELA T; MUFSON EJ; HERSH LB; SAPER CB;
Indirizzi:
BETH ISRAEL HOSP,DEPT NEUROL,330 BROOKLINE AVE BOSTON MA 02215 BETH ISRAEL HOSP,DEPT NEUROL BOSTON MA 02215 BETH ISRAEL HOSP,PROGRAM NEUROSCI BOSTON MA 02215 HARVARD UNIV,SCH MED BOSTON MA 02115 UNIV NAVARRA,DEPT ANAT E-31080 PAMPLONA SPAIN RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT NEUROL SCI CHICAGO IL 60612 UNIV KENTUCKY,DEPT BIOCHEM LEXINGTON KY 40536
Titolo Testata:
Journal of comparative neurology
fascicolo: 3, volume: 345, anno: 1994,
pagine: 321 - 344
SICI:
0021-9967(1994)345:3<321:CIITHH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTORS; HUMAN BASAL FOREBRAIN; HUMAN CEREBRAL-CORTEX; NORMAL HUMAN-BRAIN; AREA 35 CORTICES; ALZHEIMERS-DISEASE; RHESUS-MONKEY; ACETYLCHOLINESTERASE-RICH; RAT HIPPOCAMPUS; NUCLEUS BASALIS;
Keywords:
LIMBIC SYSTEM; ACETYLCHOLINESTERASE; CHOLINE ACETYLTRANSFERASE; CHOLINERGIC SYSTEM; CHEMOARCHITECTONICS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
101
Recensione:
Indirizzi per estratti:
Citazione:
S. Delacalle et al., "CHOLINERGIC INNERVATION IN THE HUMAN HIPPOCAMPAL-FORMATION INCLUDING THE ENTORHINAL CORTEX", Journal of comparative neurology, 345(3), 1994, pp. 321-344

Abstract

The cholinergic innervation of the hippocampal formation is thought to play an important role in memory processes, but its organization in humans has not been described in detail. We studied the cholinergic innervation of the human hippocampal formation by means of immunohistochemistry with polyclonal antisera directed against acetylcholinesterase(AChE), choline acetyltransferase (ChAT), and the low-affinity (p75) nerve growth factor receptor (NGFR). The density of ChAT-like immunoreactive (ChAT-li) fibers differed substantially among the various regions, in general paralleling the pattern of AChE-li staining. One notable exception was the presence of AChE-li cell bodies. In contrast, ChATimmunoreactivity was associated only with fibers and terminals. NGFR-li staining corresponded closely to the ChAT-li fiber pattern. ChAT-lifibers in the CA fields diffusely filled the stratum pyramidale and extended into the stratum oriens and radiatum as well. The highest density was consistently observed in CA4 and CA3 subfields. Staining decreased from CA4 to CA1 and was substantially less dense in the subicularcomplex. In the entorhinal cortex, the ChAT- and NGFR-li fiber innervation displayed a laminar pattern, most intense over the nests of cells in layer II. There was a trend towards an age-related reduction in the density of ChAT- and AChE-li fibers and terminals. Nonetheless, we also found a surprisingly conserved NGFR-li innervation and the presence of occasional NGFR-li pyramidal cells, providing evidence of a plastic response in the brains of the elderly patients. (C) 1994 Wiley-Liss, Inc.

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Documento generato il 26/01/20 alle ore 01:05:28