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Titolo:
SELECTIVE INNER HAIR CELL OTOTOXICITY INDUCED BY CARBOPLATIN
Autore:
WAKE M; TAKENO S; IBRAHIM D; HARRISON R;
Indirizzi:
SUNNYBROOK HLTH SCI CTR,A208,2075 BAYVIEW AVE TORONTO M4N 3M5 ON CANADA HOSP SICK CHILDREN,DEPT OTOLARYNGOL TORONTO M5G 1X8 ON CANADA HOSP SICK CHILDREN,AUDITORY SCI LAB TORONTO M5G 1X8 ON CANADA
Titolo Testata:
The Laryngoscope
fascicolo: 4, volume: 104, anno: 1994,
pagine: 488 - 493
SICI:
0023-852X(1994)104:4<488:SIHCOI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CISPLATIN; ANALOGS; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
M. Wake et al., "SELECTIVE INNER HAIR CELL OTOTOXICITY INDUCED BY CARBOPLATIN", The Laryngoscope, 104(4), 1994, pp. 488-493

Abstract

Carboplatin is a second-generation platinum an tineoplastic agent. Ithas biological activity similar to cisplatin and is currently recommended for the treatment of ovarian cancer. In clinical use, carboplatinappears less ototoxic than cisplatin. This paper reports the ototoxiceffects of carboplatin, in doses equivalent to the clinical use of the drug, in the chinchilla. Intravenous carboplatin 200 to 400 mg/m(2) by bolus injection caused significant ototoxicity in this model as revealed by brainstem evoked responses (ABR audiometry). The cochlear pathology as seen by scanning electron microscopy revealed predominantly inner hair cell (IHC) stereocilia damage. Furthermore, the extent (grade) of the morphological lesions appears to be well correlated with the auditory brainstem response pattern of threshold elevation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:13:21