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Titolo:
CONTRIBUTION OF RED-BLOOD-CELL AGGREGATION TO VENOUS VASCULAR-RESISTANCE IN SKELETAL-MUSCLE
Autore:
CABEL M; MEISELMAN HJ; POPEL AS; JOHNSON PC;
Indirizzi:
UNIV CALIF SAN DIEGO,DEPT BIOENGN LA JOLLA CA 92093 UNIV ARIZONA,COLL MED,DEPT PHYSIOL TUCSON AZ 85724 UNIV SO CALIF,SCH MED,DEPT PHYSIOL & BIOPHYS LOS ANGELES CA 90033 JOHNS HOPKINS UNIV,SCH MED,DEPT BIOMED ENGN BALTIMORE MD 21205
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 2, volume: 41, anno: 1997,
pagine: 1020 - 1032
SICI:
0363-6135(1997)41:2<1020:CORATV>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT RHEOLOGICAL BEHAVIOR; NARROW HORIZONTAL TUBES; SHEAR RATE; ERYTHROCYTE AGGREGATION; APPARENT VISCOSITY; PRESSURE REDUCTION; CREMASTER MUSCLE; VERTICAL TUBES; FLOW; CAT;
Keywords:
VENOUS VASCULAR CONDUCTANCE; BLOOD FLOW REGULATION; BLOOD RHEOLOGY; CAPILLARY PRESSURE; VENOUS PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
M. Cabel et al., "CONTRIBUTION OF RED-BLOOD-CELL AGGREGATION TO VENOUS VASCULAR-RESISTANCE IN SKELETAL-MUSCLE", American journal of physiology. Heart and circulatory physiology, 41(2), 1997, pp. 1020-1032

Abstract

The effects of red blood cell aggregation on venous vascular resistance and conductance were examined in the cat lateral gastrocnemius muscle. During perfusion with blood of normal hematocrit, venous conductance fell linearly by 41% when blood flow was reduced from 5 to 1 ml . min(-1). 100 g tissue(-1) and increased linearly by 155% when flow was increased from 5 to 20 ml . min(-1). 100 g tissue(-1). This effect wasnot seen when the muscle was perfused with an acellular solution of 12% Dextran 40 in Ringer solution and was greatly reduced or absent with a nonaggregating suspension of red blood cells in Ringer solution + Dextran 40. Also, the venous vascular conductance at a control flow of5 ml . min(-1). 100 g tissue(-1) during perfusion with the nonaggregating red blood cell suspension was twice that with normal blood of thesame hematocrit. The effect of flow on venous conductance was significantly reduced when red blood cell aggregation was increased by addition of Dextran 250 to the blood (200 mg/kg body wt) and was also reduced in animals with systemic hematocrit >50%. These findings suggest that red blood cell aggregation contributes importantly to venous vascular resistance in resting muscle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:52:40