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Titolo:
ANTIULCEROGENICITY OF THE FLAVONOID FRACTION FROM BIDENS AUREA - COMPARISON WITH RANITIDINE AND OMEPRAZOLE
Autore:
DELALASTRA CA; MARTIN MJ; LACASA C; MOTILVA V;
Indirizzi:
UNIV SEVILLA,FAC FARM,FARMACODINAM LAB,C PROF GARCIA GONZALEZ E-41012SEVILLE SPAIN
Titolo Testata:
Journal of ethnopharmacology
fascicolo: 3, volume: 42, anno: 1994,
pagine: 161 - 168
SICI:
0378-8741(1994)42:3<161:AOTFFF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ZINC ACEXAMATE; STRESS; RAT; SOPHORADIN; ULCER;
Keywords:
FLAVONOIDS; BIDENS AUREA; ASTERACEAE; STRESS ULCER; GASTRIC MUCUS; HISTOMORPHOMETRIC EVALUATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Delalastra et al., "ANTIULCEROGENICITY OF THE FLAVONOID FRACTION FROM BIDENS AUREA - COMPARISON WITH RANITIDINE AND OMEPRAZOLE", Journal of ethnopharmacology, 42(3), 1994, pp. 161-168

Abstract

Effects of the flavonoid fraction of Bidens aurea (Aiton) Sherff on gastric ulceration induced by restraint and cold were studied in rats. Mucosal damage was evaluated histomorphometrically and the results were compared with those of omeprazole and ranitidine. The effects of these agents on the quantity and quality of the gastric mucus were also determined histologically and biochemically. Oral treatment with the ether fraction of the flavonoid extract gave the highest level of gastric protection. Mucus content was increased and accompanied by a proportional increase in proteins and hexosamines. There was also a marked increase of the periodic acid-Shiff (PAS) area (neutral glycoprotein) and the alcian blue (AB) area (sulphated glycoprotein). The groups whichreceived ranitidine and omeprazole did not overcome the inhibition ofthe mucus secretion induced in this experimental model.

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Documento generato il 28/11/20 alle ore 03:49:42