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Titolo:
NITRIC OXIDE-MEDIATED VASODILATION IN HUMAN-PREGNANCY
Autore:
WILLIAMS DJ; VALLANCE PJT; NEILD GH; SPENCER JAD; IMMS FJ;
Indirizzi:
MIDDLESEX HOSP,DIV NEPHROL,INST UROL & NEPHROL,MORTIMER ST LONDON W1N8AA ENGLAND UNIV COLL LONDON,SCH MED,DEPT NEPHROL LONDON W1N 8AA ENGLAND UNIV COLL LONDON,SCH MED,DEPT CLIN PHARMACOL LONDON W1N 8AA ENGLAND UNIV COLL LONDON,SCH MED,DEPT OBSTET & GYNECOL LONDON W1N 8AA ENGLAND UNITED MED & DENT SCH,SHERRINGTON SCH PHYSIOL LONDON ENGLAND
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 2, volume: 41, anno: 1997,
pagine: 748 - 752
SICI:
0363-6135(1997)41:2<748:NOVIH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL ARTERIOLAR TONE; VASCULAR REACTIVITY; L-ARGININE; SYNTHASES; HYPERTENSION; INDUCTION; VOLUME; SERIAL; WOMEN; RATS;
Keywords:
ENDOTHELIUM-DERIVED RELAXING FACTOR; CARDIOVASCULAR COMPLICATIONS; PLETHYSMOGRAPHY; VASCULAR RESISTANCE; VASOMOTOR SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Williams et al., "NITRIC OXIDE-MEDIATED VASODILATION IN HUMAN-PREGNANCY", American journal of physiology. Heart and circulatory physiology, 41(2), 1997, pp. 748-752

Abstract

The maternal circulation vasodilates during pregnancy. We investigated the contribution of nitric oxide to this vasodilatation. Using venous occlusion plethysmography, we measured the effect of nitric oxide synthase inhibition on hand blood flow during human pregnancy. We compared the response to a brachial artery infusion of the nitric oxide synthase inhibitor NG-monomethyl-L-arginine (L-NMMA) with the response to norepinephrine in three groups of women: nonpregnant, early pregnant (9-15 wk), and late pregnant (36-41 wk). Basal hand blood flow increased significantly during late pregnancy compared with nonpregnant and early pregnant subjects (P = 0.007). L-NMMA produced a greater reductionin hand blood flow in both pregnant groups compared with nonpregnant controls (P = 0.0003). Norepinephrine produced an attenuated response in late pregnancy compared with nonpregnant and early pregnant women (P = 0.0029). If other vascular beds respond in the same way as the hand, the gestational increase in vasoconstrictor response to L-NMMA thatwe observed implicates increased generation of nitric oxide in the fall of peripheral vascular resistance during healthy human pregnancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:43:26