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Titolo:
CANINE PULMONARY VASOREACTIVITY TO SEROTONIN - ROLE OF PROTEIN-KINASE-C AND TYROSINE KINASE
Autore:
BARMAN SA; PAULY JR; ISALES CM;
Indirizzi:
MED COLL GEORGIA,DEPT PHARMACOL & TOXICOL AUGUSTA GA 30912
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 2, volume: 41, anno: 1997,
pagine: 740 - 747
SICI:
0363-6135(1997)41:2<740:CPVTS->2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE; DOG LUNG; VASCULAR BED; INHIBITORS; RESPONSES; 5-HYDROXYTRYPTAMINE; CONTRACTIONS; VERAPAMIL; RECEPTORS; BLOCKADE;
Keywords:
VOLTAGE-DEPENDENT CALCIUM CHANNELS; VASOCONSTRICTION; PULMONARY VASCULAR RESISTANCE; PULMONARY VASCULAR COMPLIANCE; PULMONARY CAPILLARY PRESSURE; STAUROSPORINE; GENISTEIN; TYRPHOSTIN 25; KETANSERIN; VERAPAMIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Barman et al., "CANINE PULMONARY VASOREACTIVITY TO SEROTONIN - ROLE OF PROTEIN-KINASE-C AND TYROSINE KINASE", American journal of physiology. Heart and circulatory physiology, 41(2), 1997, pp. 740-747

Abstract

The role of protein kinase C- and protein tyrosine kinase-mediated signal transduction in the canine pulmonary vascular response to serotonin (5-HT) was determined in the isolated blood-perfused dog lung. Pulmonary vascular resistances and compliances were measured with vascularocclusion techniques. 5-HT (10(-5) M) significantly increased precapillary resistance by similar to 150% and postcapillary resistance twofold and significantly decreased total vascular compliance to similar to50% of control values by decreasing large-vessel compliance and middle-compartment compliance. The 5-HT2-receptor blocker ketanserin (10(-7) M), the protein kinase C inhibitor staurosporine (10(-7) M), the voltage-dependent Ca2+-channel blocker verapamil (10(-5) M), and the specific protein tyrosine kinase inhibitors genistein (5 x 10(-4) M) and tyrphostin 25 (5 x 10(-4) M) completely inhibited the presser response to 5-HT, whereas the 5-HT1-receptor antagonist (-)pindolol (10(-7) M) had no significant effect on the serotonergic response. These results indicate that the canine pulmonary vascular response to 5-HT involves activation of 5-HT2 receptors and suggests that this receptor signal transduction pathway involves protein kinase C and tyrosine kinase and the activation of voltage-dependent Ca2+ channels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 13:37:52