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Titolo:
BFGF RESTORES ENDOTHELIUM-DEPENDENT RESPONSES OF HYPERCHOLESTEROLEMICRABBIT THORACIC AORTA
Autore:
MEURICE T; BAUTERS C; VALLET B; CORSEAUX D; VANBELLE E; HAMON M; DUPUIS B; LABLANCHE JM; BERTRAND ME;
Indirizzi:
SERV CARDIOL & HEMODYNAM B,BLVD PROF J LECLERCQ F-59037 LILLE FRANCE UNIV LILLE,DEPT PHARMACOL F-59037 LILLE FRANCE UNIV LILLE,DEPT CARDIOL F-59037 LILLE FRANCE UNIV LILLE,DEPT ANESTHESIOL F-59037 LILLE FRANCE
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 2, volume: 41, anno: 1997,
pagine: 613 - 617
SICI:
0363-6135(1997)41:2<613:BREROH>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; CHOLESTEROL-FED RABBITS; SMOOTH-MUSCLE CELLS; RAT CAROTID-ARTERY; REGENERATED ENDOTHELIUM; ILIAC ARTERY; L-ARGININE; RELAXATION; PROLIFERATION; INJURY;
Keywords:
FIBROBLAST GROWTH FACTOR; VASODILATION; VASCULAR ENDOTHELIUM; ACETYLCHOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
T. Meurice et al., "BFGF RESTORES ENDOTHELIUM-DEPENDENT RESPONSES OF HYPERCHOLESTEROLEMICRABBIT THORACIC AORTA", American journal of physiology. Heart and circulatory physiology, 41(2), 1997, pp. 613-617

Abstract

In animal models, a hypercholesterolemic diet induces areas of deendothelialization and impairs endothelium-dependent vasorelaxation. Angiogenic growth factors increase endothelial cell growth in vivo. This study was thus designed to test the hypothesis that chronic administration of basic fibroblast growth factor (bFGF) in hypercholesterolemic rabbits might restore normal physiological responses to endothelium-dependent agonists. After feeding on a 2% cholesterol diet for 6 wk, 14 New Zealand White rabbits received twice-weekly intravenous boluses of either 2.5 mu g bFGF (hypercholesterolemic bFGF group, n = 6) or placebo (hypercholesterolemic control group, n = 8) for 3 wk and were killedfor assessment of in vitro vasoreactivity and for histological analysis. Six animals fed with standard rabbit diet were used to assess normal responses. Endothelium-dependent responses to acetylcholine and to the calcium ionophore A-23187 were reduced in the hypercholesterolemiccontrol group compared with normal rabbits. Hypercholesterolemic animals treated with bFGF had significantly better endothelium-dependent responses than hypercholesterolemic rabbits not treated with bFGF. Endothelium-independent responses did not differ significantly among the three groups. A similar degree of plaque formation was observed in control- and bFGF-treated hypercholesterolemic rabbits. These results showthat, in this model of atherosclerosis, bFGF has a highly beneficial effect on the functional responses of atherosclerotic vessels and doesnot have a deleterious effect on the degree of plaque formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:38:21