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Titolo:
AMYLIN GIVEN BY CENTRAL AND PERIPHERAL ROUTES INHIBITS ACID GASTRIC-SECRETION
Autore:
GUIDOBONO F; COLUZZI M; PAGANI F; PECILE A; NETTI C;
Indirizzi:
UNIV MILAN,DEPT PHARMACOL CHEMOTHERAPY & MED TOXICOL,VIA VANVITELLI 32 I-20129 MILAN ITALY
Titolo Testata:
Peptides
fascicolo: 4, volume: 15, anno: 1994,
pagine: 699 - 702
SICI:
0196-9781(1994)15:4<699:AGBCAP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; ISLET AMYLOID POLYPEPTIDE; CALCITONIN GENE; BINDING-SITES; INSULIN; RAT; IAPP; SOMATOSTATIN; RESISTANCE; PROTEIN;
Keywords:
AMYLIN; ACID GASTRIC SECRETION; PYLORUS LIGATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
F. Guidobono et al., "AMYLIN GIVEN BY CENTRAL AND PERIPHERAL ROUTES INHIBITS ACID GASTRIC-SECRETION", Peptides, 15(4), 1994, pp. 699-702

Abstract

The effect of rat amylin on acid gastric secretion in the pylorus-ligated, unanesthetized rat system (Shay test) was examined. Amylin administered peripherally (2.5, 5, 10, 40, 100, or 160 mu g/kg, SC) or intracerebroventricularly (1.5, 2.7, or 5 mu g/rat, ICV) decreased acid gastric secretion in a dose-dependent manner. Central administration of amylin gave a stronger suppression of gastric secretion than peripheral injection. In addition, ICV-injected amylin inhibited insulin-stimulated acid gastric secretion and was effective in suppressing acid gastric secretion in rats depleted of somatostatin by pretreatment with cysteamine. This study suggests that amylin may participate in the central regulation of acid gastric secretion and indicates a possible biological function of amylin as a gastrointestinal peptide.

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Documento generato il 19/02/20 alle ore 21:14:53