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Titolo:
BIOSYNTHETIC-PATHWAY OF 19-NORALDOSTERONE IN ISOLATED RAT GLOMERULOSACELLS
Autore:
TAKEDA Y; MIYAMORI I; IKI K; YONEDA T; TAKEDA R;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 2,TAKARA MACHI KANAZAWA 920 JAPAN
Titolo Testata:
Journal of steroid biochemistry and molecular biology
fascicolo: 1, volume: 49, anno: 1994,
pagine: 69 - 71
SICI:
0960-0760(1994)49:1<69:BO1IIR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALDOSTERONE-PRODUCING ADENOMA; HYPERTENSINOGENIC ACTIVITY; URINARY-EXCRETION; 18,19-DIHYDROXYCORTICOSTERONE; 18-HYDROXY-19-NORCORTICOSTERONE; 19-NOR-ALDOSTERONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takeda et al., "BIOSYNTHETIC-PATHWAY OF 19-NORALDOSTERONE IN ISOLATED RAT GLOMERULOSACELLS", Journal of steroid biochemistry and molecular biology, 49(1), 1994, pp. 69-71

Abstract

The biosynthetic pathway of 19-noraldosterone (19-noraldo) in isolated rat glomerulosa cells (GC) and fasciculata-reticular cells (FC) was studied by analyzing [C-14]pregnenolone metabolism using HPLC and quantification by specific RIA. In GCs, 18,19-dihydroxycorticosterone was detected after 15 min incubation with [C-14]pregnenolone, 18-hydroxy-19-norcorticosterone was detected after 30 min and 19-noraldo was detected after 45 min before the appearance of an aldosterone peak. These three mineralocorticoids were not detected in FCs. The results demonstrate that 19-noraldo is synthesized in GCs and then undergoes further metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:26:33