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Titolo:
AN AUTORADIOGRAPHIC STUDY OF THE DIFFERENTIAL-EFFECTS OF N-ETHOXYCARBONYL-2-ETHOXY-1,2-DIHYDROQUINOLINE (EEDQ) ON STRIATAL AND EXTRASTRIATAL D-1 AND D-2 DOPAMINE-RECEPTORS IN THE RAT
Autore:
GNANALINGHAM KK; HUNTER AJ; JENNER P; MARSDEN CD;
Indirizzi:
UNIV LONDON KINGS COLL,DIV BIOMED SCI,PHARMACOL GRP,PARKINSONS DIS SOC EXPTL RES LABS,MANRESA RD LONDON SW3 6LX ENGLAND UNIV LONDON KINGS COLL,DIV BIOMED SCI,PHARMACOL GRP,PARKINSONS DIS SOC EXPTL RES LABS LONDON SW3 6LX ENGLAND SMITHKLINE BEECHAM PHARMACEUT HARLOW CM19 5AD ESSEX ENGLAND UNIV LONDON,NATL HOSP NEUROL,DEPT CLIN NEUROL LONDON ENGLAND
Titolo Testata:
Neuropharmacology
fascicolo: 5, volume: 33, anno: 1994,
pagine: 647 - 655
SICI:
0028-3908(1994)33:5<647:AASOTD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TREATED MALE-RATS; SELECTIVE PROTECTION; BASAL GANGLIA; HIGH-AFFINITY; BRAIN; D1; AGONISTS; INACTIVATION; BINDING; INVIVO;
Keywords:
EEDQ; D-1/D-2 DOPAMINE RECEPTORS; AUTORADIOGRAPHY; STRIATUM; EXTRASTRIATAL AREAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
K.K. Gnanalingham et al., "AN AUTORADIOGRAPHIC STUDY OF THE DIFFERENTIAL-EFFECTS OF N-ETHOXYCARBONYL-2-ETHOXY-1,2-DIHYDROQUINOLINE (EEDQ) ON STRIATAL AND EXTRASTRIATAL D-1 AND D-2 DOPAMINE-RECEPTORS IN THE RAT", Neuropharmacology, 33(5), 1994, pp. 647-655

Abstract

The effect of in vivo administration of the alkylating agent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) on striatal and extrastriatal D-1 and D-2 dopamine (DA) receptors was investigated in the rat. N-ethoxycarbonyl-2-ethoxy-1,1-dihydroquinoline treatment reduced specific [H-3]SCH 23390 -8-hydroxy-2,3,4,5-tetrahydro-3-methyl-1-phenyl-1-H-3-benzazepine) binding to D-1 DA receptors in the striatum (42-46% of saline-treated controls), entopeduncular nucleus (20%) and substantia nigra pars reticulata (23%). Similarly, specific [H-3]spiperone binding to D-2 DA receptors was decreased in the striatum (28-37% of saline-treated controls). However, [H-3]spiperone binding in the substantia nigra pars compacta (67%) was much less affected. In vivo pretreatment with the D-1 DA antagonist SCH 23390 selectively and dose dependently protected [H-3]SCH 23390 binding against the effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in the striatal/extrastriatal regions. Pretreatment with the D-2 DA antagonist raclopride or the D-2 DA agonist quinpirole selectively protected [H-3]spiperone binding. In contrast, pretreatment with the D-1 DA agonist SKF 23390 roxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine) not only protected [H-3]-SCH 23390binding but at very high doses protected striatal [H-3]spiperone binding. The differential alkylating effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline on striatal vs extrastriatal D-1 and D-2 DA receptors may be related to their post- (striatal DA receptors) and pre-synaptic (extrastriatal DA receptors) localizations, respectively. The present results further demonstrate that in vivo, SCH 23390 and raclopride/quinpirole retain their D-1 and D-2 DA receptor selectivity.

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Documento generato il 18/01/20 alle ore 10:47:38