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Titolo:
THE COMPETITIVE NMDA ANTAGONIST, D-CPP-ENE, POTENTIATES THE ANTICONVULSANT ACTIVITY OF CONVENTIONAL ANTIEPILEPTICS AGAINST MAXIMAL ELECTROSHOCK-INDUCED SEIZURES IN MICE
Autore:
ZARNOWSKI T; KLEINROK Z; TURSKI WA; CZUCZWAR SJ;
Indirizzi:
MARIE CURIE SKLODOWSKA UNIV,DEPT PHARMACOL,JACZEWSKIEGO 8 PL-20090 LUBLIN POLAND MARIE CURIE SKLODOWSKA UNIV,DEPT PHARMACOL PL-20090 LUBLIN POLAND
Titolo Testata:
Neuropharmacology
fascicolo: 5, volume: 33, anno: 1994,
pagine: 619 - 624
SICI:
0028-3908(1994)33:5<619:TCNADP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID ANTAGONISTS; RECEPTOR ANTAGONISTS; EPILEPSY; DRUGS; CGP-37849; CGP-39551; MK-801; MODEL; VALPROATE; ENHANCE;
Keywords:
ANTIEPILEPTICS; CARBAMAZEPINE; DIAZEPAM; DIPHENYLHYDANTOIN; PHENOBARBITAL; VALPROATE; D-CPP-ENE; NMDA RECEPTOR; SEIZURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
T. Zarnowski et al., "THE COMPETITIVE NMDA ANTAGONIST, D-CPP-ENE, POTENTIATES THE ANTICONVULSANT ACTIVITY OF CONVENTIONAL ANTIEPILEPTICS AGAINST MAXIMAL ELECTROSHOCK-INDUCED SEIZURES IN MICE", Neuropharmacology, 33(5), 1994, pp. 619-624

Abstract

D-CPP-ene (2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid; a competitive antagonist of N-methyl-D-aspartic acid] in a dose of 2 mg/kg (i.p.) significantly increased the threshold for electroconvulsions. When given in a dose half that affecting the electroconvulsive threshold, D-CPP-ene potentiated the anticonvulsant activity of carbamazepine, diazepam, diphenylhydantoin, phenobarbital and valproate against maximal electroshock (50 mA)-induced seizures in mice. However, this NMDA antagonist did not influence the plasma levels of the antiepilepticdrugs studied, so a pharmacokinetic interaction, in terms of total plasma levels at least, is not probable. The chimney test and retention testing in mice revealed that the combined treatment of D-CPP-ene at 1.0 mg/kg (i.p.) with either diazepam, diphenylhydantoin, phenobarbitalor valproate (providing a 50% protection against maximal electroshockconvulsions) resulted in motor impairment and caused impairment of long-term memory, On the other hand, a combination of D-CPP-ene and carbamazepine was devoid of adverse effects. It can be concluded that the potential utility of D-CPP-ene in combination with conventional antiepileptic drugs does not seem promising, except for carbamazepine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:30:10