Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PROTECTION FROM HIGH-PRESSURE INDUCED HYPEREXCITABILITY BY THE AMPA KAINATE RECEPTOR ANTAGONISTS GYKI-52466 AND LY-293558
Autore:
PEARCE PC; MACLEAN CJ; SHERGILL HK; WARD EM; HALSEY MJ; TINDLEY G; PEARSON J; MELDRUM BS;
Indirizzi:
MRC,CLIN RES CTR,ANAESTHESIA HPNS GRP,WATFORD RD HARROW HA1 3UJ MIDDXENGLAND MRC,CLIN RES CTR,MED STAT SECT HARROW HA1 3UJ MIDDX ENGLAND INST PSYCHIAT,DEPT NEUROL LONDON SE5 8AF ENGLAND
Titolo Testata:
Neuropharmacology
fascicolo: 5, volume: 33, anno: 1994,
pagine: 605 - 612
SICI:
0028-3908(1994)33:5<605:PFHIHB>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID ANTAGONISTS; NEUROLOGICAL SYNDROME; PRIMATE MODEL; RAT; 2,3-BENZODIAZEPINE; GYKI-52466; RESPONSES; SYSTEM; NMDA;
Keywords:
HIGH PRESSURE NEUROLOGICAL SYNDROME (HPNS); PRIMATES; RATS; AMPA KAINATE RECEPTORS; GYKI 52466; LY 293558; BEHAVIORAL OBSERVATIONS; EEG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
P.C. Pearce et al., "PROTECTION FROM HIGH-PRESSURE INDUCED HYPEREXCITABILITY BY THE AMPA KAINATE RECEPTOR ANTAGONISTS GYKI-52466 AND LY-293558", Neuropharmacology, 33(5), 1994, pp. 605-612

Abstract

The neurophysiological effects of 2 novel AMPA/kainate receptor antagonists, GYKI 52466 and LY 293558, on the high pressure neurological syndrome have been investigated in the rat and baboon (GYKI 52466) and rat (LY 293558). Rats were exposed to increasing ambient pressures of helium and oxygen at 3 ATA/min, on one occasion each. GYKI 52466 at 20 mu mol/kg i.v. immediately before, followed by 70 mu mol/kg/hr i.v. during compression delayed tremor by 85% and myoclonus by 30%, compared with control vehicle, and no side effects were observed. Seizure activity was not affected by any of the doses used. LY 293558 at 36 mu mol/kg i.p. delayed tremor and myoclonus (44% and 12%), LY 293558 72 mu mol/kg additionally delayed seizure activity (21%). Side effects, principally tranquillization at the higher dose, were also noted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 03:34:20