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Titolo:
DIFFERENTIAL TRANSCRIPTION, WITHOUT REPLICATION, OF NONSTRUCTURAL ANDSTRUCTURAL GENES OF HUMAN PARVOVIRUS B19 IN THE UT7 EPO CELL-LINE AS DEMONSTRATED BY IN-SITU HYBRIDIZATION/
Autore:
LERUEZ M; PALLIER C; VASSIAS L; ELOUET JF; ROMEO P; MORINET F;
Indirizzi:
HOP ST LOUIS,MICROBIOL SERV,1 RUE CLAUDE VELLEFAUX F-75010 PARIS FRANCE HOP ST LOUIS,MICROBIOL SERV F-75010 PARIS FRANCE HOP HENRI MONDOR,INSERM,U91 F-94010 CRETEIL FRANCE
Titolo Testata:
Journal of General Virology
, volume: 75, anno: 1994,
parte:, 6
pagine: 1475 - 1478
SICI:
0022-1317(1994)75:<1475:DTWRON>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROPAGATION; INVITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
M. Leruez et al., "DIFFERENTIAL TRANSCRIPTION, WITHOUT REPLICATION, OF NONSTRUCTURAL ANDSTRUCTURAL GENES OF HUMAN PARVOVIRUS B19 IN THE UT7 EPO CELL-LINE AS DEMONSTRATED BY IN-SITU HYBRIDIZATION/", Journal of General Virology, 75, 1994, pp. 1475-1478

Abstract

Erythroid progenitor cells are the main target for B19 parvovirus infection. The UT7 cell line demonstrates a marked erythroid differentiation on induction by erythropoietin (EPO) (UT7/EPO cells) and thereforeappears to be a potential target for B19 parvovirus. We aimed to evaluate the presence and localization of B19 nucleic acids in UT7/EPO cells by in situ hybridization. Three digoxigenin-labelled probes were used: two recognized specifically the non-structural region of the B19 genome and one probe was structural region-specific. In our experiment UT7/EPO cells were not permissive to B19 infection. Transcription led to nonstructural and structural gene transcripts without DNA replication or capsid protein synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:23:35