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Titolo:
MRI DETECTS ACUTE DEGENERATION OF THE NIGROSTRIATAL DOPAMINE SYSTEM AFTER MPTP EXPOSURE IN HEMIPARKINSONIAN MONKEYS
Autore:
MILETICH RS; BANKIEWICZ KS; QUARANTELLI M; PLUNKETT RJ; FRANK J; KOPIN IJ; DICHIRO G;
Indirizzi:
NIH,DIAGNOST RADIOL RES LAB,9000 ROCKVILLE PIKE,BLDG 10,ROOM 1C451 BETHESDA MD 20892 NINCDS,NEUROIMAGING BRANCH BETHESDA MD 00000 NINCDS,SURG NEUROL BRANCH BETHESDA MD 00000 NINCDS,CLIN NEUROSCI BRANCH BETHESDA MD 00000
Titolo Testata:
Annals of neurology
fascicolo: 6, volume: 35, anno: 1994,
pagine: 689 - 697
SICI:
0364-5134(1994)35:6<689:MDADOT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR MAGNETIC-RESONANCE; PARKINSONISM-INDUCING NEUROTOXIN; BRAIN EDEMA; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; RHESUS-MONKEY; PRIMATE BRAIN; ASTROCYTE RESPONSE; GLOBUS-PALLIDUS; MOUSE-BRAIN; RAT-BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
R.S. Miletich et al., "MRI DETECTS ACUTE DEGENERATION OF THE NIGROSTRIATAL DOPAMINE SYSTEM AFTER MPTP EXPOSURE IN HEMIPARKINSONIAN MONKEYS", Annals of neurology, 35(6), 1994, pp. 689-697

Abstract

Exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can cause an acute chemical toxicity resulting in a parkinsonian state in humans and nonhuman primates. We wished to assess whether the toxicity from MPTP is associated with changes on magnetic resonance images of brain structures containing dopamine neuronal processes or with disrupture of the blood-brain barrier. Normal rhesus monkeys and monkeys at various times after being subjected to unilateral intracarotid injection of MPTP (0.4 mg/kg) were studied with magnetic resonance imaging using T1- and T2-weighted spin-echo and gradient-echo sequences. Disrupture of the blood-brain barrier was assessed also with magnetic resonance imaging after administration of gadolinium-diethylenetriamine pentaacetic acid. Parkinsonian symptoms contralateral to the infused carotidusually appeared within 1 day after MPTP exposure, reaching their peak severity by 7 days, when all monkeys showed clear clinical abnormalities. Magnetic resonance imaging changes developed in concomitance with the clinical signs and were characterized by increased signal intensity on T2-weighted images as well as decreased intensity on T1-weighted images of the ipsilateral caudate and putamen. T2 hyperintensity wasalso present just dorsal to the pars compacta of the substantia nigra, in the region of the proximal nigrostriatal tract. All magnetic resonance imaging changes dissipated in the next 2 weeks. There were no abnormalities at any time in the globus pallidus, nucleus actumbens, andother structures innervated by the mesocorticolimbic dopamine system. After MPTP exposure, there was no evidence of blood-brain barrier disrupture, suggesting that vasogenic edema was an unlikely factor in theproduction of the observed abnormalities. The signal intensity changes on magnetic resonance images are most probably asociated with cytotoxic edema caused by the acute MPTP-induced degeneration of nigrostriatal dopamine nerve terminals and axons. Follow-up by magnetic resonanceimaging, to 3 years after MPTP infusion, failed to reveal any residual abnormalities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 02:09:53