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Titolo:
POLYMORPHISMS OF THE ANGIOTENSIN-CONVERTING-ENZYME GENE IN SUBJECTS WHO DIE FROM CORONARY HEART-DISEASE
Autore:
EVANS AE; POIRIER O; KEE F; LECERF L; MCCRUM E; FALCONER T; CRANE J; OROURKE DF; CAMBIEN F;
Indirizzi:
BELFAST MONICA PROJECT,DEPT EPIDEMIOL & PUBL HLTH,GROSVENOR RD BELFAST BT12 4BJ ANTRIM NORTH IRELAND INSERM,SC7 PARIS FRANCE QUEENS UNIV BELFAST,DEPT FORENS PATHOL BELFAST ANTRIM NORTH IRELAND QUEENS UNIV BELFAST,DEPT PATHOL BELFAST ANTRIM NORTH IRELAND
Titolo Testata:
Quarterly Journal of Medicine
fascicolo: 4, volume: 87, anno: 1994,
pagine: 211 - 214
SICI:
1460-2725(1994)87:4<211:POTAGI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSERTION DELETION POLYMORPHISM; MYOCARDIAL-INFARCTION; CELLS; RISK; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
A.E. Evans et al., "POLYMORPHISMS OF THE ANGIOTENSIN-CONVERTING-ENZYME GENE IN SUBJECTS WHO DIE FROM CORONARY HEART-DISEASE", Quarterly Journal of Medicine, 87(4), 1994, pp. 211-214

Abstract

It has been shown that myocardial infarction survivors are more likely to carry an insertion/deletion polymorphism (I/D) of the angiotensin-converting-enzyme (ACE) gene than age-matched population controls. Totest whether the association with coronary risk had been under-estimated, the frequency of the ACE I/D was studied in 213 fatal cases of definite and possible myocardial infarction which came to autopsy in theBelfast MONICA Project area. In comparison to controls from the same population, the autopsy cases had an increased frequency of the ACE D allele (p < 0.02). The overall odds ratios were 2.2 for DD vs. II, and1.8 for ID vs II (test for trends p = 0.01). The findings bear out the hypothesis that the ACE I/D polymorphism is a risk factor for fatal myocardial infarction and sudden cardiac death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:54:18