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Titolo:
STUDIES ON THE DISTRIBUTION OF IMMUNE CELLS IN THE UTERI OF PREPUBERTAL AND CYCLING GILTS
Autore:
BISCHOF RJ; BRANDON MR; LEE CS;
Indirizzi:
UNIV MELBOURNE,SCH VET SCI,CTR ANIM BIOTECHNOL PARKVILLE VIC 3052 AUSTRALIA UNIV MELBOURNE,SCH VET SCI,CTR ANIM BIOTECHNOL PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
Journal of reproductive immunology
fascicolo: 2, volume: 26, anno: 1994,
pagine: 111 - 129
SICI:
0165-0378(1994)26:2<111:SOTDOI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORCINE LYMPHOCYTES-T; MONOCLONAL-ANTIBODIES; INTRAEPITHELIAL LYMPHOCYTES; INTRAUTERINE INFUSION; LITTER SIZE; SHEEP; PIG; ANTIGENS; SUBSETS; SWINE;
Keywords:
PIG; UTERUS; LOCAL UTERINE IMMUNE SYSTEM; ENDOMETRIAL LEUKOCYTES; ESTROUS CYCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Bischof et al., "STUDIES ON THE DISTRIBUTION OF IMMUNE CELLS IN THE UTERI OF PREPUBERTAL AND CYCLING GILTS", Journal of reproductive immunology, 26(2), 1994, pp. 111-129

Abstract

To establish the cellular basis for the local immune response in the porcine uterus, immunohistochemical studies using a panel of monoclonal antibodies to pig leukocytes were conducted on uterine tissues from prepubertal and cycling gilts. In prepubertal uteri, neutrophils were the most predominant cell type, while MHC class II+ cells and CD2(+) Tlymphocytes were also common. At the early-stage of the oestrous cycle, CD2(+) T cells were numerous in the endometrium, particularly in the uterine epithelium and subepithelial regions. However, by the mid-stage of the cycle there was a significant and dramatic fall in CD2(+) Tcells and other lymphocytes expressing the CD4, CD8 and CD1 phenotypes, MHC class II+ cells were predominant throughout the endometrium. During late oestrus there was a dramatic infiltration of neutrophils into the subepithelial stroma. A distinct increase in the CD2(+) intraepithelial T lymphocyte population was also observed at this stage of thecycle. It was concluded that in the healthy, non-pregnant pig uterus T lymphocytes, macrophages and neutrophils were the prominent leukocyte cell types and their migration and distribution in the uterus was strongly influenced by the oestrous cycle. These immune cells may play an important interactive role in the cyclic cellular changes in both the structure and function of the endometrium. Furthermore, the leukocyte phenotypes found in the porcine endometrium indicate that a local cellular immune response could be elicited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:34:15