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Titolo:
NUMA, A NUCLEAR-PROTEIN INVOLVED IN MITOSIS AND NUCLEAR REFORMATION
Autore:
COMPTON DA; CLEVELAND DW;
Indirizzi:
DARTMOUTH COLL,SCH MED,DEPT BIOCHEM HANOVER NH 03755 JOHNS HOPKINS UNIV,SCH MED,DEPT BIOL CHEM BALTIMORE MD 21205
Titolo Testata:
Current opinion in cell biology
fascicolo: 3, volume: 6, anno: 1994,
pagine: 343 - 346
SICI:
0955-0674(1994)6:3<343:NANIIM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOTIC APPARATUS PROTEIN; MONOCLONAL-ANTIBODY; SPN ANTIGEN; PTK2 CELLS; SPINDLE; MICROINJECTION; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Compton e D.W. Cleveland, "NUMA, A NUCLEAR-PROTEIN INVOLVED IN MITOSIS AND NUCLEAR REFORMATION", Current opinion in cell biology, 6(3), 1994, pp. 343-346

Abstract

NuMA, a nuclear protein that associates with the mitotic apparatus, was identified in 1980 as a high molecular weight component of the nuclear matrix with the unusual property of associating with the microtubules of the spindle apparatus during mitosis. Over the past two years, a burst of interest in this intriguing protein has led to the clear documentation of its cell cycle redistribution, determination of its primary sequence, elucidation of its cell cycle dependent targeting domains, as well as disruption of its function through antibody microinjection and expression of dominant-negative mutants. Together, these data support a central role for NuMA in both mitotic-spindle dynamics and the reformation of the daughter cell nuclei at the end of mitosis.

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Documento generato il 22/10/20 alle ore 08:16:43