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Titolo:
PARASYMPATHETIC NONADRENERGIC, NONCHOLINERGIC REFLEX SECRETION OF PAROTID ACINAR GRANULES IN RATS PRETREATED WITH ATROPINE AND ADRENOCEPTORANTAGONISTS
Autore:
ASZTELY A; TOBIN G; EKSTROM J;
Indirizzi:
GOTHENBURG UNIV,DEPT PHARMACOL,MEDICINAREGATAN 7 S-41390 GOTHENBURG SWEDEN GOTHENBURG UNIV,DEPT PHARMACOL S-41390 GOTHENBURG SWEDEN
Titolo Testata:
Regulatory peptides
fascicolo: 3, volume: 51, anno: 1994,
pagine: 255 - 262
SICI:
0167-0115(1994)51:3<255:PNNRSO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL PEPTIDE; SALIVARY-GLANDS; SUPER-SENSITIVITY; EVOKED SECRETION; SUBSTANCE-P; DENERVATION; AMYLASE;
Keywords:
SALIVARY GLAND; NANC TRANSMITTER; REFLEX SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
A. Asztely et al., "PARASYMPATHETIC NONADRENERGIC, NONCHOLINERGIC REFLEX SECRETION OF PAROTID ACINAR GRANULES IN RATS PRETREATED WITH ATROPINE AND ADRENOCEPTORANTAGONISTS", Regulatory peptides, 51(3), 1994, pp. 255-262

Abstract

In parotid glands of fasted rats, feeding for 60-90 min reduced numerical density of acinar secretory granules by 52% and total activity ofglandular amylase by 38%. In the presence of adrenoceptor antagonists(phentolamine and propranolol, 2 mg/kg, i.p., of each) the corresponding decrease was 31% and 32%, and in combination with atropine (1 mg/kg, i.p.) 32% as to both these indices. These non-adrenergic non-cholinergic (NANC) responses depended on an intact parasympathetic auriculo-temporal nerve since they did not occur following section of this nerve. In anaesthetized animals, electrical stimulation of the sympatheticinnervation (50 Hz, 1 s every 10th second) for 60 min caused secretion of parotid saliva and decreases in number of acinar granules, by 65%, and in total amylase activity, by 49%; the adrenoceptor antagonists at the above-mentioned doses completely abolished the expected responses of the parotid gland and thus showing that these antagonists at thedose level chosen achieved an effective receptor blockade. In conclusion, parasympathetic NANC mechanisms are reflexly mobilized in response to eating, and these mechanisms are potentially responsible for the whole parasympathetic response and for the major part of that responsein the absence of any antagonists. Under natural reflex conditions adrenergic, cholinergic and non-adrenergic, non-cholinergic mechanisms are most likely engaged to varying extents in order to generate the most purposeful response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 09:26:35