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Titolo:
THE NATURAL-HISTORY OF ALZHEIMERS-DISEASE - DESCRIPTION OF STUDY COHORT AND ACCURACY OF DIAGNOSIS
Autore:
BECKER JT; BOLLER F; LOPEZ OL; SAXTON J; MCGONIGLE KL; MOOSSY J; HANIN I; WOLFSON SK; DETRE K; HOLLAND A; GUR D; LATCHAW R; BRENNER R;
Indirizzi:
UNIV PITTSBURGH,MED CTR,DEPT PSYCHIAT,NEUROPSYCHOL RES PROGRAM,SUITE 502,IROQUOIS BLDG PITTSBURGH PA 15213 UNIV PITTSBURGH,MED CTR,DEPT NEUROL PITTSBURGH PA 15213
Titolo Testata:
Archives of neurology
fascicolo: 6, volume: 51, anno: 1994,
pagine: 585 - 594
SICI:
0003-9942(1994)51:6<585:TNOA-D>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MILD SENILE DEMENTIA; DEPRESSED SUBJECTS; EARLY-ONSET; PROGRESSION; PREDICTORS; IMPAIRMENT; CRITERIA; FEATURES; SIGNS; RATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
J.T. Becker et al., "THE NATURAL-HISTORY OF ALZHEIMERS-DISEASE - DESCRIPTION OF STUDY COHORT AND ACCURACY OF DIAGNOSIS", Archives of neurology, 51(6), 1994, pp. 585-594

Abstract

Objective: We describe the sampling, initial evaluation, and final diagnostic classification of subjects enrolled in a natural history study of Alzheimer's disease (AD). Design: Volunteer cohort study. Setting: Multidisciplinary behavioral neurology research clinic. Patients or Other Participants: Three-hundred nineteen individuals were enrolled in the Alzheimer Research Program between March 1983 and March 1988. Ofthese, 204 were originally classified with AD, 102 were normal elderly control subjects, and 13 were considered special cases. Main OutcomeMeasures: Final consensus clinical diagnosis, final neuropathologic diagnosis, and death. Results: Of the 204 patients enrolled in the study, re-review after as many as 5 years of follow-up resulted in a finalclinical classification of 188 with probable AD. Seven patients were believed to have a significant vascular component to the dementia, three were found to have developed depression, and six were excluded on other clinical grounds. Neuropathologic examination of 50 brains indicated definite AD in 43. After removing these seven misdiagnosed patients, the final group of probable/definite AD totaled 181 individuals. Accuracy of the baseline clinical diagnosis relative to neuropathology was 86%, and when follow-up clinical data were considered, 91.4%. Detailed neuropsychological testing yielded high sensitivity (0.988) and specificity (0.983) to dementia. Analyses of survival time from study entry until death revealed that older patients were significantly more likely to die during follow-up, but neither sex, years of education, nor pattern of cognitive impairment were related to survival. Conclusions: These data provide the descriptive basis for future studies of thiscohort. They indicate that longitudinal follow-up of demented cases increases accuracy of diagnosis, and that detailed cognitive testing aids in early classification.

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Documento generato il 28/11/20 alle ore 18:44:49